Cerebellar TMS in Treatment of a Patient with Cerebellar Ataxia: Evidence from Clinical, Biomechanics and Neurophysiological Assessments

被引：37

作者：

Farzan, Faranak ^{[1
,2
]}

Wu, Yunfen ^{[1
,2
,3
]}

Manor, Brad ^{[1
,2
]}

Anastasio, Elana M. ^{[1
,2
]}

Lough, Matthew ^{[1
,2
]}

Novak, Vera ^{[1
,2
]}

Greenstein, Patricia E. ^{[1
,2
]}

Pascual-Leone, Alvaro ^{[1
,2
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

[3] Hosp Univ Marques de Valdecilla, Santander, Spain

来源：

CEREBELLUM | 2013年 / 12卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Ataxia; TMS; Cerebellum; EMG; Motor Cortex; TRANSCRANIAL MAGNETIC STIMULATION; MACHADO-JOSEPH-DISEASE; SPINOCEREBELLAR ATAXIA; LATE ONSET; DEGENERATION; HISTORY; MOTOR;

D O I：

10.1007/s12311-013-0485-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We describe a patient with a probable diagnosis of idiopathic late-onset cerebellar atrophy who shows improvement of limb coordination, speech, and gait following 21 days of transcranial magnetic stimulation (TMS) applied to scalp regions presumably corresponding to the cerebellum. This case study provides, for the first time, a quantitative assessment of gait improvement in response to TMS therapy in ataxia, as well as neurophysiological evidence in support of modification of cerebellar-cortical interaction that may underlie some of the improvements.

引用

页码：707 / 712

页数：6

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