Studies on tridecaptin B1, a lipopeptide with activity against multidrug resistant Gram-negative bacteria

被引：47

作者：

Cochrane, Stephen A. ^{[1
]}

Lohans, Christopher T. ^{[1
]}

van Belkum, Marco J. ^{[1
]}

Bels, Manon A. ^{[1
]}

Vederas, John C. ^{[1
]}

机构：

[1] Univ Alberta, Dept Chem, Edmonton, AB T6E 2M9, Canada

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 21期

基金：

加拿大自然科学与工程研究理事会;

关键词：

GENUS BACILLUS; CAMPYLOBACTER-JEJUNI; FATTY-ACIDS; ANTIBIOTICS; A(1);

D O I：

10.1039/c5ob00780a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Previously other groups had reported that Paenibacillus polymyxa NRRL B-30507 produces SRCAM 37, a type IIA bacteriocin with antimicrobial activity against Campylobacter jejuni. Genome sequencing and isolation of antimicrobial compounds from this P. polymyxa strain show that the antimicrobial activity is due to polymyxins and tridecaptin B-1. The complete structural assignment, synthesis, and antimicrobial profile of tridecaptin B-1 is reported, as well as the putative gene cluster responsible for its biosynthesis. This peptide displays strong activity against multidrug resistant Gram-negative bacteria, a finding that is timely to the current problem of antibiotic resistance.

引用

页码：6073 / 6081

页数：9

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