Expeditious, potentially primordial, aminoacylation of nucleotides

被引：50

作者：

Biron, JP

Parkes, LL

Pascal, R

Sutherland, JD

机构：

[1] Univ Montpellier 2, Dept Chim, UMR 5073, F-34095 Montpellier, France

[2] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 41期

关键词：

amino acids; cyclization; N-carboxyanhydrides; ribonucleotides; RNA;

D O I：

10.1002/anie.200501591

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) In the beginning: Mixed carboxylic phosphoric anhydrides 3, formed from 3′-nucleotides 1 and amino acid N-carboxyanhydrides 2, undergo competing rearrangement to 2′-aminoacyl esters 4 and cyclization to 2′,3′-cyclic phosphates 5. The intramolecular aminoacyl transfer is faster than the cyclization despite the ease with which 2′,3′-cyclic phosphates are formed through any other form of phosphate activation. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：6731 / 6734

页数：4

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