Repetitive on-demand drug release by magnetic heating of iron oxide containing polymeric implants

被引：18
作者：
Rovers, Stefan A. [2 ]
Hoogenboom, Richard [1 ,3 ]
Kemmere, Maartje F. [2 ]
Keurentjes, Jos T. F. [2 ]
机构：
[1] Dolphys Med, NL-5612 AZ Eindhoven, Netherlands
[2] Eindhoven Univ Technol, Proc Dev Grp, Dept Chem Engn & Chem, NL-5600 MB Eindhoven, Netherlands
[3] Dept Organ Chem, Supramol Chem Grp, B-9000 Ghent, Belgium
来源：
SOFT MATTER | 2012年 / 8卷 / 05期
关键词：
INSULIN RELEASE; DELIVERY; ULTRASOUND; NANOPARTICLES; MEMBRANES; HYDROGELS; DESIGN;
D O I：
10.1039/c2sm06557f
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Drug release from a polymeric matrix has been externally triggered using an alternating magnetic field in order to develop an on-demand drug delivery implant. Superparamagnetic iron oxide nanoparticles have been distributed in a poly(methyl methacrylate) core, coated with a thermoresponsive layer of poly(butyl methacrylate-stat-methyl methacrylate) containing ibuprofen as a model drug. The release rate of ibuprofen reversibly increased, up to 25-fold, upon exposure to the magnetic field and was found to increase with higher iron oxide loading. Finally, magnetically triggered on-demand drug release was demonstrated under physiologically relevant conditions, namely 37 degrees C in PBS buffer with high ibuprofen content in the implant and only 15 minutes triggering time.
引用
收藏
页码：1623 / 1627
页数：5
相关论文
共 33 条
[21]   Biomedical nanoparticle carriers with combined thermal and magnetic responses [J].
Liu, Ting-Yu ;
Hu, Shang-Hsiu ;
Liu, Dean-Mo ;
Chen, San-Yuan ;
Chen, I-Wei .
NANO TODAY, 2009, 4 (01) :52-65
[22]   Regulated insulin release from biodegradable dextran hydrogels containing poly(ethylene glycol) [J].
Moriyama, K ;
Yui, N .
JOURNAL OF CONTROLLED RELEASE, 1996, 42 (03) :237-248
[23]   Thermosensitive magnetic polymer particles as contactless controllable drug carriers [J].
Müller-Schulte, D ;
Schmitz-Rode, T .
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2006, 302 (01) :267-271
[24]   Design of a core-shelled polymer cylinder for potential programmable drug delivery [J].
Qiu, LY ;
Zhu, KJ .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2001, 219 (1-2) :151-160
[25]   Relaxation processes of superparamagnetic iron oxide nanoparticles in liquid and incorporated in poly(methyl methacrylate) [J].
Rovers, Stefan A. ;
Hoogenboom, Richard ;
Kemmere, Maartje F. ;
Keurentjes, Jos T. F. .
JOURNAL OF PHYSICAL CHEMISTRY C, 2008, 112 (40) :15643-15646
[26]   Influence of Distribution on the Heating of Superparamagnetic Iron Oxide Nanoparticles in Poly(methyl methacrylate) in an Alternating Magnetic Field [J].
Rovers, Stefan A. ;
Dietz, Carin H. J. T. ;
van der Poel, Leon A. M. ;
Hoogenboom, Richard ;
Kemmere, Maartje F. ;
Keurentjes, Jos T. F. .
JOURNAL OF PHYSICAL CHEMISTRY C, 2010, 114 (18) :8144-8149
[27]   Characterization and Magnetic Heating of Commercial Superparamagnetic Iron Oxide Nanoparticles [J].
Rovers, Stefan A. ;
van der Poel, Leon A. M. ;
Dietz, Carin H. J. T. ;
Noijen, Jef J. ;
Hoogenboom, Richard ;
Kemmere, Maartje F. ;
Kopinga, Klaas ;
Keurentjes, Jos T. F. .
JOURNAL OF PHYSICAL CHEMISTRY C, 2009, 113 (33) :14638-14643
[28]   A controlled-release microchip [J].
Santini, JT ;
Cima, MJ ;
Langer, R .
NATURE, 1999, 397 (6717) :335-338
[29]   MAGNETICALLY RESPONSIVE MICROSPHERES FOR THE PULSED DELIVERY OF INSULIN [J].
SASLAWSKI, O ;
WEINGARTEN, C ;
BENOIT, JP ;
COUVREUR, P .
LIFE SCIENCES, 1988, 42 (16) :1521-1528
[30]   Magnetic hydrogel nanocomposites for remote controlled pulsatile drug release [J].
Satarkar, Nitin S. ;
Hilt, J. Zach .
JOURNAL OF CONTROLLED RELEASE, 2008, 130 (03) :246-251
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