Repetitive on-demand drug release by magnetic heating of iron oxide containing polymeric implants

被引：18

作者：

Rovers, Stefan A. ^{[2
]}

Hoogenboom, Richard ^{[1
,3
]}

Kemmere, Maartje F. ^{[2
]}

Keurentjes, Jos T. F. ^{[2
]}

机构：

[1] Dolphys Med, NL-5612 AZ Eindhoven, Netherlands

[2] Eindhoven Univ Technol, Proc Dev Grp, Dept Chem Engn & Chem, NL-5600 MB Eindhoven, Netherlands

[3] Dept Organ Chem, Supramol Chem Grp, B-9000 Ghent, Belgium

来源：

SOFT MATTER | 2012年 / 8卷 / 05期

关键词：

INSULIN RELEASE; DELIVERY; ULTRASOUND; NANOPARTICLES; MEMBRANES; HYDROGELS; DESIGN;

D O I：

10.1039/c2sm06557f

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Drug release from a polymeric matrix has been externally triggered using an alternating magnetic field in order to develop an on-demand drug delivery implant. Superparamagnetic iron oxide nanoparticles have been distributed in a poly(methyl methacrylate) core, coated with a thermoresponsive layer of poly(butyl methacrylate-stat-methyl methacrylate) containing ibuprofen as a model drug. The release rate of ibuprofen reversibly increased, up to 25-fold, upon exposure to the magnetic field and was found to increase with higher iron oxide loading. Finally, magnetically triggered on-demand drug release was demonstrated under physiologically relevant conditions, namely 37 degrees C in PBS buffer with high ibuprofen content in the implant and only 15 minutes triggering time.

引用

页码：1623 / 1627

页数：5

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