Interferon signatures in immune disorders and disease

被引：26
作者：
Forster, Samuel [1 ]
机构：
[1] Monash Univ, Ctr Innate Immun & Infect Dis, Monash Inst Med Res, Melbourne, Vic 3168, Australia
来源：
IMMUNOLOGY AND CELL BIOLOGY | 2012年 / 90卷 / 05期
基金：
英国医学研究理事会;
关键词：
type I interferons; interferon signatures; systems biology; disease signatures; CHRONIC HEPATITIS-C; SYSTEMIC-LUPUS-ERYTHEMATOSUS; IMMUNODEFICIENCY-VIRUS TYPE-1; ALPHA-2A PLUS RIBAVIRIN; IFN-STIMULATED GENE-15; TOLL-LIKE RECEPTORS; EPSTEIN-BARR-VIRUS; I INTERFERON; MYCOBACTERIUM-TUBERCULOSIS; MICROARRAY ANALYSIS;
D O I：
10.1038/icb.2012.12
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The interferon (IFN) family and the type-I IFNs specifically have an important and well-characterized role in antiviral defence, immune modulation and cell-cycle control and are regularly applied in the clinical context. Advances in high-content technologies have facilitated an enhanced understanding of the global IFN response capable of being induced. Recent application of these technologies is improving our understanding of the specificity and subtleties associated with this response. This review considers our current understanding of the temporal gene profile induced through IFN stimulation across a diversity of disease conditions including autoimmune diseases, bacterial and viral infections. Understanding these signatures, the disease-specific differences and the biological effects induced has the potential to facilitate IFN-driven therapeutic development. Immunology and Cell Biology (2012) 90, 520-527; doi:10.1038/icb.2012.12; published online 10 April 2012
引用
收藏
页码：520 / 527
页数：8
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