Medulloblastoma/Primitive Neuroectodermal Tumor and Germ Cell Tumors The Uncommon but Potentially Curable Primary Brain Tumors

被引:4
作者
Samkari, Ayman [2 ,3 ,4 ]
Hwang, Eugene [2 ,3 ,4 ]
Packer, Roger J. [1 ,2 ,4 ]
机构
[1] Childrens Natl Med Ctr, Ctr Neurosci & Behav Med, Div Neurol, Washington, DC 20010 USA
[2] Childrens Natl Med Ctr, Brain Tumor Inst, Div Neurol, Washington, DC 20010 USA
[3] Childrens Natl Med Ctr, Div Hematol & Oncol, Ctr Canc & Blood Disorders, Washington, DC 20010 USA
[4] George Washington Univ, Sch Med & Hlth Sci, Washington, DC 20037 USA
关键词
Medulloblastoma; Primitive neuroectodermal tumor; Pineoblastoma; Germ cell tumor; HIGH-DOSE CHEMOTHERAPY; COMPARATIVE GENOMIC HYBRIDIZATION; CRANIOSPINAL RADIATION-THERAPY; PROSPECTIVE RANDOMIZED-TRIAL; YOUNG-CHILDREN; MYELOABLATIVE CHEMOTHERAPY; PROGNOSTIC-FACTORS; POSTOPERATIVE CHEMOTHERAPY; CHILDHOOD MEDULLOBLASTOMA; MAINTENANCE CHEMOTHERAPY;
D O I
10.1016/j.hoc.2012.04.002
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
This article presents an overview of medulloblastomas, central nervous system primitive neuroectodermal tumors, and germ cell tumors for the practicing oncologist. Discussion includes the definition of these tumors, histopathologic findings, molecular and genetic characteristics, prognoses, and evolution of treatment.
引用
收藏
页码:881 / +
页数:16
相关论文
共 100 条
[71]   Malignant germ cell tumours of childhood: new associations of genomic imbalance [J].
Palmer, R. D. ;
Foster, N. A. ;
Vowler, S. L. ;
Roberts, I. ;
Thornton, C. M. ;
Hale, J. P. ;
Schneider, D. T. ;
Nicholson, J. C. ;
Coleman, N. .
BRITISH JOURNAL OF CANCER, 2007, 96 (04) :667-676
[72]   The Genetic Landscape of the Childhood Cancer Medulloblastoma [J].
Parsons, D. Williams ;
Li, Meng ;
Zhang, Xiaosong ;
Jones, Sian ;
Leary, Rebecca J. ;
Lin, Jimmy Cheng-Ho ;
Boca, Simina M. ;
Carter, Hannah ;
Samayoa, Josue ;
Bettegowda, Chetan ;
Gallia, Gary L. ;
Jallo, George I. ;
Binder, Zev A. ;
Nikolsky, Yuri ;
Hartigan, James ;
Smith, Doug R. ;
Gerhard, Daniela S. ;
Fults, Daniel W. ;
VandenBerg, Scott ;
Berger, Mitchel S. ;
Marie, Suely Kazue Nagahashi ;
Shinjo, Sueli Mieko Oba ;
Clara, Carlos ;
Phillips, Peter C. ;
Minturn, Jane E. ;
Biegel, Jaclyn A. ;
Judkins, Alexander R. ;
Resnick, Adam C. ;
Storm, Phillip B. ;
Curran, Tom ;
He, Yiping ;
Rasheed, B. Ahmed ;
Friedman, Henry S. ;
Keir, Stephen T. ;
McLendon, Roger ;
Northcott, Paul A. ;
Taylor, Michael D. ;
Burger, Peter C. ;
Riggins, Gregory J. ;
Karchin, Rachel ;
Parmigiani, Giovanni ;
Bigner, Darell D. ;
Yan, Hai ;
Papadopoulos, Nick ;
Vogelstein, Bert ;
Kinzler, Kenneth W. ;
Velculescu, Victor E. .
SCIENCE, 2011, 331 (6016) :435-439
[73]  
Peyrl A, 2010, NEURO-ONCOLOGY, V12, pII44
[74]   Outcome Prediction in Pediatric Medulloblastoma Based on DNA Copy-Number Aberrations of Chromosomes 6q and 17q and the MYC and MYCN Loci [J].
Pfister, Stefan ;
Remke, Marc ;
Benner, Axel ;
Mendrzyk, Frank ;
Toedt, Grischa ;
Felsberg, Joerg ;
Wittmann, Andrea ;
Devens, Frauke ;
Gerber, Nicolas U. ;
Joos, Stefan ;
Kulozik, Andreas ;
Reifenberger, Guido ;
Rutkowski, Stefan ;
Wiestler, Otmar D. ;
Radlwimmer, Bernhard ;
Scheurlen, Wolfram ;
Lichter, Peter ;
Korshunov, Andrey .
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (10) :1627-1636
[75]   Upregulation of SOX2, NOTCH1, and ID1 in supratentorial primitive neuroectodermal tumors: a distinct differentiation pattern from that of medulloblastomas Clinical article [J].
Phi, Ji Hoon ;
Kim, Jin Hyun ;
Eun, Kyoung Mi ;
Wang, Kyu-Chang ;
Park, Ki Ho ;
Choi, Seung Ah ;
Kim, Young Yim ;
Park, Sung-Hye ;
Cho, Byung-Kyu ;
Kim, Seung-Ki .
JOURNAL OF NEUROSURGERY-PEDIATRICS, 2010, 5 (06) :608-614
[76]   Childhood brain tumors: epidemiology, current management and future directions [J].
Pollack, Ian F. ;
Jakacki, Regina I. .
NATURE REVIEWS NEUROLOGY, 2011, 7 (09) :495-506
[77]   Is there a role for high dose chemotherapy with hematopoietic stem cell rescue in patients with relapsed supratentorial PNET? [J].
Raghuram, C. P. ;
Moreno, L. ;
Zacharoulis, S. .
JOURNAL OF NEURO-ONCOLOGY, 2012, 106 (03) :441-447
[78]  
Reddy AT, 2000, CANCER, V88, P2189, DOI 10.1002/(SICI)1097-0142(20000501)88:9<2189::AID-CNCR27>3.0.CO
[79]  
2-G
[80]   FSTL5 Is a Marker of Poor Prognosis in Non-WNT/Non-SHH Medulloblastoma [J].
Remke, Marc ;
Hielscher, Thomas ;
Korshunov, Andrey ;
Northcott, Paul A. ;
Bender, Sebastian ;
Kool, Marcel ;
Westermann, Frank ;
Benner, Axel ;
Cin, Huriye ;
Ryzhova, Marina ;
Sturm, Dominik ;
Witt, Hendrik ;
Haag, Daniel ;
Toedt, Grischa ;
Wittmann, Andrea ;
Schoettler, Anna ;
von Bueren, Andre O. ;
von Deimling, Andreas ;
Rutkowski, Stefan ;
Scheurlen, Wolfram ;
Kulozik, Andreas E. ;
Taylor, Michael D. ;
Lichter, Peter ;
Pfister, Stefan M. .
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (29) :3852-3861