Medulloblastoma/Primitive Neuroectodermal Tumor and Germ Cell Tumors The Uncommon but Potentially Curable Primary Brain Tumors

被引:4
作者
Samkari, Ayman [2 ,3 ,4 ]
Hwang, Eugene [2 ,3 ,4 ]
Packer, Roger J. [1 ,2 ,4 ]
机构
[1] Childrens Natl Med Ctr, Ctr Neurosci & Behav Med, Div Neurol, Washington, DC 20010 USA
[2] Childrens Natl Med Ctr, Brain Tumor Inst, Div Neurol, Washington, DC 20010 USA
[3] Childrens Natl Med Ctr, Div Hematol & Oncol, Ctr Canc & Blood Disorders, Washington, DC 20010 USA
[4] George Washington Univ, Sch Med & Hlth Sci, Washington, DC 20037 USA
关键词
Medulloblastoma; Primitive neuroectodermal tumor; Pineoblastoma; Germ cell tumor; HIGH-DOSE CHEMOTHERAPY; COMPARATIVE GENOMIC HYBRIDIZATION; CRANIOSPINAL RADIATION-THERAPY; PROSPECTIVE RANDOMIZED-TRIAL; YOUNG-CHILDREN; MYELOABLATIVE CHEMOTHERAPY; PROGNOSTIC-FACTORS; POSTOPERATIVE CHEMOTHERAPY; CHILDHOOD MEDULLOBLASTOMA; MAINTENANCE CHEMOTHERAPY;
D O I
10.1016/j.hoc.2012.04.002
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
This article presents an overview of medulloblastomas, central nervous system primitive neuroectodermal tumors, and germ cell tumors for the practicing oncologist. Discussion includes the definition of these tumors, histopathologic findings, molecular and genetic characteristics, prognoses, and evolution of treatment.
引用
收藏
页码:881 / +
页数:16
相关论文
共 100 条
[51]  
Louis DN, 2007, WHO Classification of Tumours of the Central Nervous System, P309
[52]   Clinical Experience With Hedgehog Pathway Inhibitors [J].
Low, Jennifer A. ;
de Sauvage, Frederic J. .
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (36) :5321-5326
[53]   EXTRANEURAL METASTASES FROM MEDULLOBLASTOMA - LONG-TERM SURVIVAL AFTER SEQUENTIALLY SCHEDULED CHEMOTHERAPY AND RADIOTHERAPY [J].
MAHONEY, DH ;
STEUBER, CP ;
SANDBACH, JF ;
FERNBACH, DJ .
MEDICAL AND PEDIATRIC ONCOLOGY, 1986, 14 (06) :329-331
[54]   Supratentorial embryonal tumors in children under 5 years of age: An SFOP study of treatment with postoperative chemotherapy alone [J].
Marec-Berard, P ;
Jouvet, A ;
Thiesse, P ;
Kalifa, C ;
Doz, F ;
Frappaz, D .
MEDICAL AND PEDIATRIC ONCOLOGY, 2002, 38 (02) :83-90
[55]   Intensive chemotherapy and bone marrow rescue for young children with newly diagnosed malignant brain tumors [J].
Mason, WP ;
Grovas, A ;
Halpern, S ;
Dunkel, IJ ;
Garvin, J ;
Heller, G ;
Rosenblum, M ;
Gardner, S ;
Lyden, D ;
Sands, S ;
Puccetti, D ;
Lindsley, K ;
Merchant, TE ;
O'Malley, B ;
Bayer, L ;
Petriccione, MM ;
Allen, J ;
Finlay, JL .
JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (01) :210-221
[56]  
Matsutani M, 1998, Neurosurg Focus, V5, pe7
[57]   Primary intracranial germ cell tumors: A clinical analysis of 153 histologically verified cases [J].
Matsutani, M ;
Sano, K ;
Takakura, K ;
Fujimaki, T ;
Nakamura, O ;
Funata, N ;
Seto, T .
JOURNAL OF NEUROSURGERY, 1997, 86 (03) :446-455
[58]   Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma [J].
Miller, Suzanne ;
Rogers, Hazel A. ;
Lyon, Paul ;
Rand, Vikki ;
Adamowicz-Brice, Martyna ;
Clifford, Steven C. ;
Hayden, James T. ;
Dyer, Sara ;
Pfister, Stefan ;
Korshunov, Andrey ;
Brundler, Marie-Anne ;
Lowe, James ;
Coyle, Beth ;
Grundy, Richard G. .
NEURO-ONCOLOGY, 2011, 13 (08) :866-879
[59]   Hedgehogs, Flies, Wnts and MYCs: The Time Has Come for Many Things in Medulloblastoma [J].
Monje, Michelle ;
Beachy, Philip A. ;
Fisher, Paul G. .
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (11) :1395-1398
[60]   Late neurocognitive sequelae in survivors of brain tumours in childhood [J].
Mulhern, RK ;
Merchant, TE ;
Gajjar, A ;
Reddick, WE ;
Kun, LE .
LANCET ONCOLOGY, 2004, 5 (07) :399-408