Rapid, General Access to Chiral β-Fluoroamines and β,β-Difluoroamines via Organocatalysis

被引：75
作者：
Fadeyi, Olugbeminiyi O.
Lindsley, Craig W. [1 ]
机构：
[1] Vanderbilt Univ, Dept Chem, Nashville, TN 37232 USA
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 04期
关键词：
FLUORINATION; DESIGN;
D O I：
10.1021/ol802930q
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A rapid, general route to enantiopure beta-fluoroamines and beta,beta-difluoroamines has been developed employing organocatalysis in both a two-pot and a one-pot procedure. Both chemical yields (64-82%) and enantioselectivity (94-98% ee) were excellent and represent a significant improvement in the art of preparing chemically diverse beta-fluoroamines from readily available precursors.
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收藏
页码：943 / 946
页数：4
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