Analysis of centrosomes in human cancer

被引：6

作者：

Duensing, Stefan ^{[1
]}

机构：

[1] Heidelberg Univ, Dept Urol, Div Mol Urooncol, Sch Med, Heidelberg, Germany

来源：

CENTROSOME & CENTRIOLE | 2015年 / 129卷

关键词：

CHROMOSOMAL INSTABILITY; AMPLIFICATION; OVERDUPLICATION; DEFECTS;

D O I：

10.1016/bs.mcb.2015.03.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Centrosomes are small cytoplasmic organelles that function as major microtubule-organizing centres during interphase and mitosis. In cancer cells, centrosomes are frequently abnormal in number, size, and structure. Numerous studies have reported centrosome aberrations in human tumors where they frequently increase with malignant progression and advanced disease stage. However, there are a number of caveats when analyzing centrosomes in human tissue. Besides the actual immunodetection and quantification of centrosomes, which can be difficult and cumbersome, centrosome aberrations require a careful evaluation in the cellular context in which they occur. This chapter highlights the importance of careful interpretation of centrosome aberrations in human tumors.

引用

页码：51 / 60

页数：10

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