Artificial Nutrition and Intestinal Mucosal Barrier Functionality

被引:29
作者
Anastasilakis, Chrysostomos D. [1 ]
Ioannidis, Orestis [3 ]
Gkiomisi, Athina I. [2 ]
Botsios, Dimitrios [3 ]
机构
[1] Aristotle Univ Thessaloniki, Gen Mil Hosp 424, Dept Pharmacol, GR-54006 Thessaloniki, Greece
[2] Aristotle Univ Thessaloniki, Gen Mil Hosp 424, Dept Obstet & Gynaecol, GR-54006 Thessaloniki, Greece
[3] Aristotle Univ Thessaloniki, Sch Med, Dept Surg 4, GR-54006 Thessaloniki, Greece
关键词
Artificial nutrition; Mucosal barrier; Mucosal immunity; Bacterial translocation; Neuropeptides; Bombesin; Neurotensin; Arginine; Glutamine; TOTAL PARENTERAL-NUTRITION; RESPIRATORY-TRACT IMMUNITY; SEVERE ACUTE-PANCREATITIS; MAJOR ABDOMINAL-TRAUMA; MULTIPLE ORGAN FAILURE; ENTERAL NUTRITION; LYMPHOID-TISSUE; BACTERIAL TRANSLOCATION; GASTROINTESTINAL-TRACT; SECRETORY COMPONENT;
D O I
10.1159/000353603
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The gastrointestinal tract has a major role in digestion and absorption of nutrients while playing a leading role in defense of the body. It forms a shield against the invasion of various microorganisms or their products (e.g. antigens, toxins) and therefore it is important to establish its integrity and functionality. That depends on the route of administration and the composition of the artificial nutrition. This study concentrates on the influences of different kinds of artificial nutrition in the functionality of the intestinal mucosa! barriers. It seems that full macromolecular solutions of enteral nutrition ensure an adequate mucous immune response, while a lack of nutritional stimulus in the lumen leads rapidly to a dysfunction of gastric-associated lymphatic tissue and mucosal immune system. This dysfunction renders the patients susceptible to infections in distant organs, hospital pneumonia, and multiorgan failure of non-infectious etiology. In patients with indication of total parenteral nutrition administration, addition of bombesin or glutamine preserves mucosal immune response and may limit the adverse effects. (C) 2013 S. Karger AG, Basel
引用
收藏
页码:193 / 208
页数:16
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