ULTRASOUND-ASSISTED, ONE-POT, FOUR-COMPONENT SYNTHESIS OF 1,4,6,8-TETRAHYDROQUINOLINES IN AQUEOUS MEDIUM

被引：14

作者：

Siddekha, Aisha ^{[1
,2
]}

Azzam, Sadeq Hamood Saleh ^{[1
]}

Pasha, M. A. ^{[1
]}

机构：

[1] Bangalore Univ, Dept Studies Chem, Bangalore 560001, Karnataka, India

[2] Smt VHD Cent Inst Home Sci, Dept Chem, Bangalore, Karnataka, India

来源：

SYNTHETIC COMMUNICATIONS | 2014年 / 44卷 / 03期

关键词：

2-Amino-3-cyano-4-aryl-5-oxo-7; 7-dimethyl-1; 4; 6; 8-tetrahydroquinolines; aromatic aldehydes; malononitrile; potassium carbonate; ultrasonication; water; MULTICOMPONENT REACTIONS; POLYHYDROQUINOLINE DERIVATIVES; SOLVENT-FREE; EFFICIENT; QUINOLONE; WATER; COPOLYMERS; INHIBITORS; CHEMISTRY; POLYMERS;

D O I：

10.1080/00397911.2013.813545

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 2-amino-3-cyano-4-aryl-5-oxo-7,7-dimethyl-1,4,6,8-tetrahydroquinolines were prepared by a one-pot, four-component condensation of aromatic aldehydes, dimedone, malononitrile, and ammonium acetate using K2CO3 as a catalyst in aqueous medium under sonic conditions. This protocol, being a single-step reaction, has the advantages of operational simplicity and minimal environmental impact. The synthesized compounds were confirmed through spectral characterization using infrared, H-1 NMR, C-13 NMR, and CHN analysis. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]

引用

页码：424 / 432

页数：9

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