ULTRASOUND-ASSISTED, ONE-POT, FOUR-COMPONENT SYNTHESIS OF 1,4,6,8-TETRAHYDROQUINOLINES IN AQUEOUS MEDIUM

被引：14
|
作者：
Siddekha, Aisha [1 ,2 ]
Azzam, Sadeq Hamood Saleh [1 ]
Pasha, M. A. [1 ]
机构：
[1] Bangalore Univ, Dept Studies Chem, Bangalore 560001, Karnataka, India
[2] Smt VHD Cent Inst Home Sci, Dept Chem, Bangalore, Karnataka, India
来源：
SYNTHETIC COMMUNICATIONS | 2014年 / 44卷 / 03期
关键词：
2-Amino-3-cyano-4-aryl-5-oxo-7; 7-dimethyl-1; 4; 6; 8-tetrahydroquinolines; aromatic aldehydes; malononitrile; potassium carbonate; ultrasonication; water; MULTICOMPONENT REACTIONS; POLYHYDROQUINOLINE DERIVATIVES; SOLVENT-FREE; EFFICIENT; QUINOLONE; WATER; COPOLYMERS; INHIBITORS; CHEMISTRY; POLYMERS;
D O I：
10.1080/00397911.2013.813545
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of 2-amino-3-cyano-4-aryl-5-oxo-7,7-dimethyl-1,4,6,8-tetrahydroquinolines were prepared by a one-pot, four-component condensation of aromatic aldehydes, dimedone, malononitrile, and ammonium acetate using K2CO3 as a catalyst in aqueous medium under sonic conditions. This protocol, being a single-step reaction, has the advantages of operational simplicity and minimal environmental impact. The synthesized compounds were confirmed through spectral characterization using infrared, H-1 NMR, C-13 NMR, and CHN analysis. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]
引用
收藏
页码：424 / 432
页数：9
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