A (6-4) photolyase model: Repair of DNA (6-4) lesions requires a reduced and deprotonated flavin

被引：0
作者：
Cichon, MK [1 ]
Arnold, S [1 ]
Carell, T [1 ]
机构：
[1] Univ Marburg, Fachbereich Chem, D-35032 Marburg, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 05期
关键词：
bioorganic chemistry; DNA; DNA repair; mutagenesis; photolyase;
D O I：
10.1002/1521-3773(20020301)41:5<767::AID-ANIE767>3.0.CO;2-B
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Photolyase-catalyzed repair of pyrimidine (6-4) photoadducts was modeled with synthetic, covalently linked flavin - oxetane 1. The repair reaction (oxetane splitting) requires the reduced flavin in its deprotonated form. The key step of the repair reaction involves an electron transfer from the flavin to the oxetane.
引用
收藏
页码：767 / +
页数：5
相关论文
共 50 条
  • [31] DNA (6-4) Photolesion Repair Occurs in the Electronic Ground State of the TT Dinucleotide Dimer Radical Anion
    Harbach, Philipp H. P.
    Borowka, Julia
    Bohnwagner, Mercedes-Vanessa
    Dreuw, Andreas
    JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2010, 1 (17): : 2556 - 2560
  • [32] Error-free replicative bypass of (6-4) photoproducts by DNA polymerase ζ in mouse and human cells
    Yoon, Jung-Hoon
    Prakash, Louise
    Prakash, Satya
    GENES & DEVELOPMENT, 2010, 24 (02) : 123 - 128
  • [33] Pyrimidine (6-4) Pyrimidone Photoproducts in UVA-Irradiated DNA: Photosensitization or Photoisomerization?
    Douki, Thierry
    CHEMPHOTOCHEM, 2020, 4 (04): : 294 - 299
  • [34] The photoreactivation of 6-4 photoproducts in chloroplast and nuclear DNA depends on the amount of the Arabidopsis UV repair defective 3 protein
    Zglobicki, Piotr
    Hermanowicz, Pawel
    Klodawska, Kinga
    Bazant, Aneta
    Labuz, Justyna
    Grzyb, Joanna
    Dutka, Malgorzata
    Kowalska, Ewa
    Jawor, Joanna
    Leja, Katarzyna
    Banas, Agnieszka Katarzyna
    BMC PLANT BIOLOGY, 2024, 24 (01):
  • [35] Crystal structure of a prokaryotic (6-4) photolyase with an Fe-S cluster and a 6,7-dimethyl-8-ribityllumazine antenna chromophore
    Zhang, Fan
    Scheerer, Patrick
    Oberpichler, Inga
    Lamparter, Tilman
    Krauss, Norbert
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (18) : 7217 - 7222
  • [36] Characterization and differential expression of CPD and 6-4 DNA photolyases in Xiphophorus species and interspecies hybrids
    Walter, Dylan J.
    Boswell, Mikki
    de Garcia, Sara M. Volk
    Walter, Sean M.
    Breitenfeldt, Erik W.
    Boswell, William
    Walter, Ronald B.
    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 2014, 163 : 77 - 85
  • [37] Photosensitization of DNA by 5-Methyl-2-Pyrimidone Deoxyribonucleoside: (6-4) Photoproduct as a Possible Trojan Horse
    Vendrell-Criado, Victoria
    Rodriguez-Muniz, Gemma M.
    Consuelo Cuquerella, M.
    Lhiaubet-Vallet, Virginie
    Miranda, Miguel A.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (25) : 6476 - 6479
  • [38] Structural Biology of DNA (6-4) Photoproducts Formed by Ultraviolet Radiation and Interactions with Their Binding Proteins
    Yokoyama, Hideshi
    Mizutani, Ryuta
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 15 (11): : 20321 - 20338
  • [39] TATA-binding protein promotes the selective formation of UV-induced (6-4)-photoproducts and modulates DNA repair in the TATA box
    Aboussekhra, A
    Thoma, F
    EMBO JOURNAL, 1999, 18 (02) : 433 - 443
  • [40] NOVEL INSIGHT INTO THE STEREOCHEMICAL PATHWAY LEADING TO (6-4) PYRIMIDINE-PYRIMIDONE PHOTOPRODUCTS IN DNA
    CLIVIO, P
    FOURREY, JL
    GASCHE, J
    FAVRE, A
    TETRAHEDRON LETTERS, 1992, 33 (12) : 1615 - 1618
12345