A (6-4) photolyase model: Repair of DNA (6-4) lesions requires a reduced and deprotonated flavin

被引：0
|
作者：
Cichon, MK [1 ]
Arnold, S [1 ]
Carell, T [1 ]
机构：
[1] Univ Marburg, Fachbereich Chem, D-35032 Marburg, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 05期
关键词：
bioorganic chemistry; DNA; DNA repair; mutagenesis; photolyase;
D O I：
10.1002/1521-3773(20020301)41:5<767::AID-ANIE767>3.0.CO;2-B
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Photolyase-catalyzed repair of pyrimidine (6-4) photoadducts was modeled with synthetic, covalently linked flavin - oxetane 1. The repair reaction (oxetane splitting) requires the reduced flavin in its deprotonated form. The key step of the repair reaction involves an electron transfer from the flavin to the oxetane.
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页码：767 / +
页数：5
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