The hbhA gene of Mycobacterium tuberculosis is specifically upregulated in the lungs but not in the spleens of aerogenically infected mice

被引：32

作者：

Delogu, G

Sanguinetti, M

Posteraro, B

Rocca, S

Zanetti, S

Fadda, G

机构：

[1] Univ Cattolica Sacro Cuore, Inst Microbiol, I-00168 Rome, Italy

[2] Univ Sassari, Inst Gen Pathol, Pathol Anat & Vet Obstet Surg Clin, I-07100 Sassari, Italy

[3] Univ Sassari, Dept Biomed Sci, I-07100 Sassari, Italy

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 05期

关键词：

D O I：

10.1128/IAI.74.5.3006-3011.2006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report that hbhA is differentially regulated during Mycobacterium tuberculosis infection. Upregulation was observed in epithelial cell infection but not in macrophage infection and in the lungs but not in the spleens of infected mice, and it was greater during the early steps of infection, when bacilli disseminate from the site of primary infection.

引用

收藏

页码：3006 / 3011

页数：6

相关论文

共 31 条

[1] PATHOGENESIS OF TUBERCULOSIS - PATHWAY TO APICAL LOCALIZATION [J].

BALASUBRAMANIAN, V ;

WIEGESHAUS, EH ;

TAYLOR, BT ;

SMITH, DW .

TUBERCLE AND LUNG DISEASE, 1994, 75 (03) :168-178

[2] PROTECTION TO MICE AFFORDED BY BCG VACCINES AGAINST AN AEROGENIC CHALLENGE BY 3 MYCOBACTERIA OF DECREASING VIRULENCE [J].

COLLINS, FM .

TUBERCLE, 1985, 66 (04) :267-276

[3] DNA vaccine combinations expressing either tissue plasminogen activator signal sequence fusion proteins or ubiquitin-conjugated antigens induce sustained protective immunity in a mouse model of pulmonary tuberculosis [J].

Delogu, G ;

Li, A ;

Repique, C ;

Collins, F ;

Morris, SL .

INFECTION AND IMMUNITY, 2002, 70 (01) :292-302

[4] Functional domains present in the mycobacterial hemagglutinin, HBHA [J].

Delogu, G ;

Brennan, MJ .

JOURNAL OF BACTERIOLOGY, 1999, 181 (24) :7464-7469

[5] The Mycobacterium tuberculosis IdeR is a dual functional regulator that controls transcription of genes involved in iron acquisition, iron storage and survival in macrophages [J].

Gold, B ;

Rodriguez, GM ;

Marras, SAE ;

Pentecost, M ;

Smith, I .

MOLECULAR MICROBIOLOGY, 2001, 42 (03) :851-865

[6] Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Guerin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara [J].

Goonetilleke, NP ;

McShane, H ;

Hannan, CM ;

Anderson, RJ ;

Brookes, RH ;

Hill, AVS .

JOURNAL OF IMMUNOLOGY, 2003, 171 (03) :1602-1609

[7] Mycobacterium bovis bacille Calmette-Guerin strains secreting listeriolysin of Listeria monocytogenes [J].

Hess, J ;

Miko, D ;

Catic, A ;

Lehmensiek, V ;

Russell, DG ;

Kaufmann, SHE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (09) :5299-5304

[8] Recombinant bacillus Calmette-Guerin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model [J].

Horwitz, MA ;

Harth, G ;

Dillon, BJ ;

Maslesa-Galic, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (25) :13853-13858

[9] Annulling a dangerous liaison: vaccination strategies against AIDS and tuberculosis [J].

Kaufmann, SHE ;

McMichael, AJ .

NATURE MEDICINE, 2005, 11 (04) :S33-S44

[10] Magnetic resonance imaging of pulmonary lesions in guinea pigs infected with Mycobacterium tuberculosis [J].

Kraft, SL ;

Dailey, D ;

Kovach, M ;

Stasiak, KL ;

Bennett, J ;

McFarland, CT ;

McMurray, DN ;

Izzo, AA ;

Orme, IM ;

Basaraba, RJ .

INFECTION AND IMMUNITY, 2004, 72 (10) :5963-5971

← 1 2 3 4 →