Golgi as an MTOC: making microtubules for its own good

被引：82

作者：

Zhu, Xiaodong ^{[1
]}

Kaverina, Irina ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Cell & Dev Biol, Nashville, TN 37232 USA

来源：

HISTOCHEMISTRY AND CELL BIOLOGY | 2013年 / 140卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Golgi; Microtubules; CLASP; AKAP450; Microtubule-organizing center; Cell polarity; GAMMA-TUBULIN; CELL-CYCLE; MOTILE CELLS; CG-NAP; NUCLEATION; COMPLEX; CENTROSOME; NETWORK; SITES; ORGANIZATION;

D O I：

10.1007/s00418-013-1119-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In cells, microtubules (MTs) are nucleated at MT-organizing centers (MTOCs). The centrosome-based MTOCs organize radial MT arrays, which are often not optimal for polarized trafficking. A recently discovered subset of non-centrosomal MTs nucleated at the Golgi has proven to be indispensable for the Golgi organization, post-Golgi trafficking and cell polarity. Here, we summarize the history of this discovery, known molecular prerequisites of MT nucleation at the Golgi and unique functions of Golgi-derived MTs.

引用

页码：361 / 367

页数：7

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