Outcomes and management of viral hepatitis and human immunodeficiency virus co-infection in liver transplantation

被引：7

作者：

Congly, Stephen E. ^{[1
]}

Doucette, Karen E. ^{[2
]}

Coffin, Carla S. ^{[1
]}

机构：

[1] Univ Calgary, Div Gastroenterol & Hepatol, Liver Unit, Calgary, AB T2N 4Z6, Canada

[2] Univ Alberta, Div Infect Dis, Edmonton, AB T6G 2R3, Canada

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2014年 / 20卷 / 02期

关键词：

Hepatitis B virus; Human immunodeficiency virus co-infection; Hepatitis C virus; Co-infection; Liver transplantation; FIBROSING CHOLESTATIC HEPATITIS; HIV-INFECTED INDIVIDUALS; SUSTAINED VIROLOGICAL RESPONSE; SOLID-ORGAN TRANSPLANTATION; INTERFERON PLUS RIBAVIRIN; TERM-FOLLOW-UP; C VIRUS; INSULIN-RESISTANCE; ANTIRETROVIRAL THERAPY; DRUG-INTERACTIONS;

D O I：

10.3748/wjg.v20.i2.414

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Liver transplantation for human immunodeficiency virus (HIV) positive patients with viral hepatitis co-infection is increasingly offered in many North American and European liver transplant centers. Prior studies have demonstrated acceptable post-transplant outcomes and no increased risk of HIV complications in patients co-infected with hepatitis B virus (HBV). However, liver transplantation in HIV positive patients with hepatitis C virus (HCV) has poorer outcomes overall, requiring careful selection of candidates. This review aims to summarize the published literature on outcomes after transplant in HIV patients with HBV or HCV related end-stage liver disease and recommendations for management. In particular the pre-transplant factors impacting outcomes in HCV/HIV co-infected candidates and importance of multidisciplinary management will be discussed. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.

引用

页码：414 / 424

页数：11

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