Cancer Stem Cells,Quo Vadis? The Notch Signaling Pathway in Tumor Initiation and Progression

被引：59
作者：
Meisel, Christian T. [1 ]
Porcheri, Cristina [1 ]
Mitsiadis, Thimios A. [1 ]
机构：
[1] Univ Zurich, Inst Oral Biol, Plattenstr 11, CH-8032 Zurich, Switzerland
来源：
CELLS | 2020年 / 9卷 / 08期
关键词：
Notch signaling pathway; cancer; stem cells; cancer stem cells; radioresistance; chemoresistance; cancer therapy; metastasis; cancer diagnosis; GAMMA-SECRETASE INHIBITORS; EPITHELIAL-MESENCHYMAL TRANSITION; ENDOTHELIAL GROWTH-FACTOR; ASYMMETRIC CELL-DIVISION; ACUTE MYELOID-LEUKEMIA; TRUNCATED INT3 GENE; BREAST-CANCER; PANCREATIC-CANCER; PROGENITOR CELLS; DOWN-REGULATION;
D O I：
10.3390/cells9081879
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The Notch signaling pathway regulates cell proliferation, cytodifferentiation and cell fate decisions in both embryonic and adult life. Several aspects of stem cell maintenance are dependent from the functionality and fine tuning of the Notch pathway. In cancer, Notch is specifically involved in preserving self-renewal and amplification of cancer stem cells, supporting the formation, spread and recurrence of the tumor. As the function of Notch signaling is context dependent, we here provide an overview of its activity in a variety of tumors, focusing mostly on its role in the maintenance of the undifferentiated subset of cancer cells. Finally, we analyze the potential of molecules of the Notch pathway as diagnostic and therapeutic tools against the various cancers.
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页码：1 / 33
页数：33
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