Unactivated C(sp3)-H hydroxylation through palladium catalysis with H2O as the oxygen source

被引：36

作者：

Hu, Jiantao ^{[1
]}

Lan, Tianlong ^{[1
]}

Sun, Yihua ^{[2
]}

Chen, Hui ^{[2
]}

Yao, Jiannian ^{[2
]}

Rao, Yu ^{[1
]}

机构：

[1] Tsinghua Univ, Sch Med, Dept Pharmacol & Pharmaceut Sci, MOE Key Lab Prot Sci, Beijing 100084, Peoples R China

[2] Chinese Acad Sci, CAS Key Lab Photochem, Inst Chem, BNLMS, Beijing 100190, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 80期

基金：

中国国家自然科学基金;

关键词：

C-H OXYGENATION; ALKANE HYDROXYLATION; BONDS; FUNCTIONALIZATION; ALKOXYLATION; ALCOHOLS; COMPLEXES; OXIDATION; CHEMISTRY; ALKENES;

D O I：

10.1039/c5cc04952k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel palladium catalyzed hydroxylation of unactivated aliphatic C(sp(3))-H bonds was successfully developed. Different from conventional methods, water serves as the hydroxyl group source in the reaction. This new reaction demonstrates good reactivity and broad functional group tolerance. The C-H hydroxylated products can be readily transformed into various highly valuable chemicals via known transformations. Based on experimental and theoretical studies, a mechanism involving the Pd(II)/(IV) pathway is proposed for this hydroxylation reaction.

引用

页码：14929 / 14932

页数：4

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