Biogenic silver nanoparticles for cancer treatment: An experimental report

被引：329

作者：

Jeyaraj, M. ^{[1
]}

Sathishkumar, G. ^{[1
]}

Sivanandhan, G. ^{[1
]}

MubarakAli, D. ^{[4
]}

Rajesh, M. ^{[1
]}

Arun, R. ^{[3
]}

Kapildev, G. ^{[1
]}

Manickavasagam, M. ^{[1
]}

Thajuddin, N. ^{[2
]}

Premkumar, K. ^{[3
]}

Ganapathi, A. ^{[1
]}

机构：

[1] Bharathidasan Univ, Sch Biotechnol, Dept Biotechnol & Genet Engn, Tiruchirappalli, Tamil Nadu, India

[2] Bharathidasan Univ, Dept Microbiol, Div Microbial Biodivers & Bioenergy, Tiruchirappalli, Tamil Nadu, India

[3] Bharathidasan Univ, Dept Biomed Sci, Canc Genet & Nanomed Lab, Tiruchirappalli, Tamil Nadu, India

[4] Mahatma Gandhi Med Coll & Res Inst Campus, Cent Interdisciplinary Res Facil CIDRF, Pondicherry, India

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2013年 / 106卷

关键词：

Biosynthesis; Sesbania grandiflora; Silver nanoparticles; FESEM; MCF-7; GREEN SYNTHESIS; PARTICLES; LATEX;

D O I：

10.1016/j.colsurfb.2013.01.027

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A generation of nanoparticles research has discussed recently. It is mandatory to elaborate the applications of biogenic nanoparticles in general and anticancereous property in particular. The present study was aimed to investigate the in vitro cytotoxicity effect of biogenic silver nanoparticles (AgNPs) against human breast cancer (MCF-7) cells towards the development of anticancer agent. Biogenic AgNPs were achieved by employing Sesbania grandiflora leaf extract as a novel reducing agent. It was well characterized by FESEM, EDAX and spectral studies showed spherical shaped nanoparticles in the size of 22 nm in slightly agglomerated form. It was surprising that biogenic AgNPs showed cytotoxic effect against MCF-7 cell lines were confirmed by MTT, AO-EB, Hochest and COMET assays. There was an immediate induction of cellular damage in terms of loss of cell membrane integrity, oxidative stress and apoptosis were found in the cell which treated with AgNPs. This may be a first report on anti-MCF-7 property of biogenic AgNPs in the fourth generation of nanoparticles research. It is necessary to study the formulation and clinical trials to establish the nano drug to treat cancer cells. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：86 / 92

页数：7

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