Risk of lymphoma subtypes after solid organ transplantation in the United States

被引:94
作者
Clarke, C. A. [1 ,2 ]
Morton, L. M. [3 ]
Lynch, C. [4 ]
Pfeiffer, R. M. [3 ]
Hall, E. C. [3 ]
Gibson, T. M. [3 ]
Weisenburger, D. D. [5 ]
Martinez-Maza, O. [6 ]
Hussain, S. K. [6 ]
Yang, J. [1 ]
Chang, E. T. [2 ]
Engels, E. A. [3 ]
机构
[1] Canc Prevent Inst Calif, Fremont, CA 94538 USA
[2] Stanford Univ, Sch Med, Dept Hlth Res & Policy & Med, Div Epidemiol, Stanford, CA 94305 USA
[3] NCI, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA
[4] Univ Iowa, Dept Epidemiol, Iowa City, IA USA
[5] City Hope Natl Med Ctr, Dept Pathol, Duarte, CA 91010 USA
[6] Univ Calif Los Angeles, Dept Epidemiol, Los Angeles, CA USA
关键词
NON-HODGKIN-LYMPHOMA; CANCER-RISK; KIDNEY-TRANSPLANT; HEPATITIS-C; IMMUNOSUPPRESSION; RECIPIENTS; REGISTRY; PEOPLE; EPIDEMIOLOGY; RELIABILITY;
D O I
10.1038/bjc.2013.294
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Solid organ transplant recipients have high risk of lymphomas, including non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). A gap in our understanding of post-transplant lymphomas involves the spectrum and associated risks of their many histologic subtypes. Methods: We linked nationwide data on solid organ transplants from the US Scientific Registry of Transplant Recipients (1987-2008) to 14 state and regional cancer registries, yielding 791 281 person-years of follow-up for 19 distinct NHL subtypes and HL. We calculated standardised incidence ratios (SIRs) and used Poisson regression to compare SIRs by recipient age, transplanted organ, and time since transplantation. Results: The risk varied widely across subtypes, with strong elevations (SIRs 10-100) for hepatosplenic T-cell lymphoma, Burkitt's lymphoma, NK/T-cell lymphoma, diffuse large B-cell lymphoma, and anaplastic large-cell lymphoma (both systemic and primary cutaneous forms). Moderate elevations (SIRs 2-4) were observed for HL and lymphoplasmacytic, peripheral T-cell, and marginal zone lymphomas, but SIRs for indolent lymphoma subtypes were not elevated. Generally, SIRs were highest for younger recipients (<20 years) and those receiving organs other than kidneys. Conclusion: Transplant recipients experience markedly elevated risk of a distinct spectrum of lymphoma subtypes. These findings support the aetiologic relevance of immunosuppression for certain subtypes and underscore the importance of detailed haematopathologic workup for transplant recipients with suspected lymphoma.
引用
收藏
页码:280 / 288
页数:9
相关论文
共 44 条
[1]   Posttransplantation lymphoproliferative disorders [J].
Andreome, P ;
Gramenzi, A ;
Lorenzini, S ;
Biselli, M ;
Cursaro, C ;
Pileri, S ;
Bernardi, M .
ARCHIVES OF INTERNAL MEDICINE, 2003, 163 (17) :1997-2004
[2]   Comparison of de novo tumours after liver transplantation with incidence rates from Italian cancer registries [J].
Baccarani, U. ;
Piselli, P. ;
Serraino, D. ;
Adani, G. L. ;
Lorenzin, D. ;
Gambato, M. ;
Buda, A. ;
Zanus, G. ;
Vitale, A. ;
De Paoli, A. ;
Cimaglia, C. ;
Bresadola, V. ;
Toniutto, P. ;
Risaliti, A. ;
Cillo, U. ;
Bresadola, F. ;
Burra, P. .
DIGESTIVE AND LIVER DISEASE, 2010, 42 (01) :55-60
[3]  
Bierman PJ, 1996, ANN ONCOL, V7, P265
[4]   AIDS-Related cancer and severity of immunosuppression in persons with AIDS [J].
Biggar, Robert J. ;
Chaturvedi, Anil K. ;
Goedert, James J. ;
Engels, Eric A. .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2007, 99 (12) :962-972
[5]   Immunosuppression and cancer: A comparison of risks in recipients of organ transplants and in HIV-positive individuals [J].
Busnach, G. ;
Piselli, P. ;
Arbustini, E. ;
Baccarani, U. ;
Burra, P. ;
Carrieri, M. P. ;
Citterio, F. ;
De Juli, E. ;
Bellelli, S. ;
Pradier, C. ;
Rezza, G. ;
Serraino, D. .
TRANSPLANTATION PROCEEDINGS, 2006, 38 (10) :3533-3535
[6]   Immunosuppression and the risk of post-transplant malignancy among cadaveric first kidney transplant recipients [J].
Bustami, RT ;
Ojo, AO ;
Wolfe, RA ;
Merion, RM ;
Bennett, WM ;
McDiarmid, SV ;
Leichtman, AB ;
Held, PJ ;
Port, FK .
AMERICAN JOURNAL OF TRANSPLANTATION, 2004, 4 (01) :87-93
[7]   Post-transplant lymphoproliferative disorders occurring after renal transplantation in adults: Report of 230 cases from the French Registry [J].
Caillard, S. ;
Lelong, C. ;
Pessione, F. ;
Moulin, B. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2006, 6 (11) :2735-2742
[8]   HIV-associated lymphomas and gamma-herpesviruses [J].
Carbone, Antonino ;
Cesarman, Ethel ;
Spina, Michele ;
Gloghini, Annunziata ;
Schulz, Thomas F. .
BLOOD, 2009, 113 (06) :1213-1224
[9]   Changes in cancer registry coding for lymphoma subtypes: Reliability over time and relevance for surveillance and study [J].
Clarke, CA ;
Undurraga, DM ;
Harasty, PJ ;
Glaser, SL ;
Morton, LM ;
Holly, EA .
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2006, 15 (04) :630-638
[10]   Expert review of non-Hodgkin's lymphomas in a population-based cancer registry: Reliability of diagnosis and subtype classifications [J].
Clarke, CA ;
Glaser, SL ;
Dorfman, RF ;
Bracci, PM ;
Eberle, E ;
Holly, EA .
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2004, 13 (01) :138-143