In vitro adhesive properties and virulence factors of Enterococcus faecalis strains

被引：77
作者：
Archimbaud, C
Shankar, N
Forestier, C
Baghdayan, A
Gilmore, MS
Charbonné, F
Joly, B
机构：
[1] Univ Auvergne, Lab Bacteriol Virol, Fac Pharm, F-63001 Clermont Ferrand, France
[2] Univ Oklahoma, Hlth Sci Ctr, Dept Pharmaceut Sci, Oklahoma City, OK 73190 USA
[3] Univ Oklahoma, Hlth Sci Ctr, Dept Ophthalmol, Oklahoma City, OK 73190 USA
[4] Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol, Oklahoma City, OK 73190 USA
[5] Univ Oklahoma, Hlth Sci Ctr, Dept Immunol, Oklahoma City, OK 73190 USA
[6] Univ Auvergne, Fac Med, F-63001 Clermont Ferrand, France
来源：
RESEARCH IN MICROBIOLOGY | 2002年 / 153卷 / 02期
关键词：
Enterococcus faecalis; adherence; aggregation substance; cytolysin; gelatinase; enterococcal surface protein;
D O I：
10.1016/S0923-2508(01)01291-8
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Twenty-nine Enterococcus faecalis isolates from patients with endocarditis or bacteremia or from stools of healthy volunteers were investigated for their ability to adhere to Int-407 and Girardi heart cell lines and for the presence of known enterococcal virulence factors. Eight strains (27.6%) adhered predominantly to Int-407 cells. The adherence of enterococci was enhanced by proteolytic digestion, suggesting that some cell binding components become surface-exposed after treatment with trypsin. The occurrence of known potential virulence factors of enterococci among these strains was determined and was as follows: enterococcal surface protein (72.4%), gelatinase (58.6%), aggregation substance (48.3%) and cytolysin (17.2%). Bacterial adherence was not significantly associated with any of these virulence factors. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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收藏
页码：75 / 80
页数：6
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