Strategies targeting the IL-4/IL-13 axes in disease

被引：166

作者：

May, Richard D. ^{[1
]}

Fung, Michael ^{[2
]}

机构：

[1] MedImmune, Resp Inflammat & Autoimmun, Cambridge CB21 6GH, England

[2] Medimmune Inc, Resp Inflammat & Autoimmun, Gaithersburg, MD 20878 USA

来源：

CYTOKINE | 2015年 / 75卷 / 01期

关键词：

Interleukin-4; Interleukin-13; Biologic; Antibody; Therapeutic; AIRWAY SMOOTH-MUSCLE; BRONCHIAL EPITHELIAL-CELLS; OBSTRUCTIVE PULMONARY-DISEASE; INNATE LYMPHOID-CELLS; NECROSIS-FACTOR-ALPHA; INFLAMMATORY-BOWEL-DISEASE; HUMAN ALVEOLAR MACROPHAGES; IL-13 RECEPTOR ALPHA-2; CD8(+) T-CELLS; SEVERE ATOPIC-DERMATITIS;

D O I：

10.1016/j.cyto.2015.05.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IL-4 and IL-13 are pleiotropic Th2 cytokines produced by a wide variety of different cell types and responsible for a broad range of biology and functions. Physiologically, Th2 cytokines are known to mediate host defense against parasites but they can also trigger disease if their activities are dysregulated. In this review we discuss the rationale for targeting the IL-4/IL-13 axes in asthma, atopic dermatitis, allergic rhinitis, COPD, cancer, inflammatory bowel disease, autoimmune disease and fibrotic disease as well as evaluating the associated clinical data derived from blocking IL-4, IL-13 or IL-4 and IL-13 together. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：89 / 116

页数：28

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