Solidification of meloxicam self-nano emulsifying drug delivery system formulation incorporated into soluble and insoluble carriers using freeze drying method

被引:7
作者
Kuncahyo, I. [1 ,2 ]
Choiri, S. [3 ]
Fudholi, A. [2 ]
机构
[1] Setiabudi Univ, Dept Pharmaceut Sci & Technol, Fac Pharm, Surakarta 57127, Indonesia
[2] Univ Gadjah Mada, Fac Pharm, Sekip Utara 55281, Yogyakarta, Indonesia
[3] Univ Sebelas Maret, Dept Pharm, Ir Sutami 36A, Surakarta 57126, Indonesia
来源
INTERNATIONAL CONFERENCE ON ADVANCED MATERIALS FOR BETTER FUTURE 2018 | 2019年 / 578卷
关键词
IN-VITRO; NANOEMULSIONS; OPTIMIZATION; DESIGN; SNEDDS;
D O I
10.1088/1757-899X/578/1/012051
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Solidification of liquid self-nano emulsifying drug delivery system (SNEDDS) formulation is required to enhance the feasibility and flexibility for further formulation processes. This study purposed to compare the soluble and insoluble carriers namely mannitol and fumed silica, respectively on the nano-emulsion formation and physical properties. The optimized SNEDDS formulation comprising of virgin olive oil, Tween 80, and PEG 400; and meloxicam was impregnated into solid carriers e.g. mannitol and fumed silica using a freeze-drying method. The physical mixture was carried out to compare the aforementioned method. Vibrational spectroscopy, thermal analysis, and morphological characteristic, droplet size and distribution, and drug release were performed to characterize the solid SNEDDS (S-SNEDDS). The result showed that crystallization of meloxicam did not observe in the S-SNEDDS formulations, which confirmed by the vibrational spectroscopy and thermal analysis. The morphological characteristic of S-SNEDDS was similar to the native carriers. The soluble carrier did not affect the formation of the nano-emulsion compared to the insoluble carrier. In addition, the S-SNEDDS enhanced the drug release of meloxicam up to 3-4 folds increment.
引用
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页数:6
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