Anterior segment optical coherence tomography evaluation of ocular graft-versus-host disease: a case study

被引：6

作者：

Li, Peng ^{[1
]}

Sun, Yichen ^{[2
,3
]}

Hariri, Sepideh ^{[1
]}

Zhou, Zhehai ^{[1
]}

Inamoto, Yoshihiro ^{[4
]}

Lee, Stephanie J. ^{[4
]}

Shen, Tueng T. ^{[1
,2
]}

Wang, Ruikang K. ^{[1
,2
]}

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[2] Univ Washington, Dept Ophthalmol, Seattle, WA 98195 USA

[3] Buddhist Tzu Chi Gen Hosp, Taipei Div, New Taipei, Taiwan

[4] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

来源：

QUANTITATIVE IMAGING IN MEDICINE AND SURGERY | 2015年 / 5卷 / 01期

关键词：

Medical and biological imaging; optical coherence tomography (OCT); ophthalmology; ocular graftversus-host disease (GVHD);

D O I：

10.3978/j.issn.2223-4292.2014.11.05

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

To explore ocular graft-versus-host disease (GVHD), anterior segment optical coherence tomography (AS-OCT) imaging of eyelids, tear meniscus, cornea and conjunctiva is performed in subsequent sessions on a patient who has ocular GVHD after allogeneic related donor stem cell transplant. The OCT results are presented together with those from a normal subject. OCT imaging is promising in visualizing several ocular GVHD manifestations, such as abnormal meibomian gland orifice (MGO), conjunctival keratinization, conjunctival hyperemia and chemosis, corneal epithelium opacification, thinning and sloughing. This case study demonstrates the capability of AS-OCT in the imaging and monitoring of ocular GVHD, which may be useful in the development of current ocular GVHD staging system and the clinical management for GVHD treatment.

引用

页码：163 / 170

页数：8

共 21 条

[1] Ultrahigh sensitive optical microangiography for in vivo imaging of microcirculations within human skin tissue beds [J].