Nitrate Therapy for Heart Failure Benefits and Strategies to Overcome Tolerance

被引：23

作者：

Gupta, Divya ^{[1
]}

Georgiopoulou, Vasiliki V. ^{[1
]}

Kalogeropoulos, Andreas P. ^{[1
]}

Marti, Catherine N. ^{[1
]}

Yancy, Clyde W. ^{[2
]}

Gheorghiade, Mihai ^{[2
]}

Fonarow, Gregg C. ^{[3
]}

Konstam, Marvin A. ^{[4
]}

Butler, Javed ^{[1
]}

机构：

[1] Emory Univ, Div Cardiol, Atlanta, GA 30322 USA

[2] Northwestern Univ, Div Cardiol, Chicago, IL 60611 USA

[3] Univ Calif Los Angeles, Div Cardiol, Los Angeles, CA USA

[4] Tufts Univ, Div Cardiol, Boston, MA 02111 USA

来源：

JACC-HEART FAILURE | 2013年 / 1卷 / 03期

关键词：

heart failure; hydralazine; nitrate; pseudotolerance; renin angiotensin aldosterone system; tolerance;

D O I：

10.1016/j.jchf.2013.03.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Combination therapy with hydralazine and nitrates can improve outcomes in patients with heart failure and low ejection fraction. However, this combination is underused in clinical practice for several reasons, including side effects related to hydralazine and polypharmacy. Some of the benefits seen with hydralazine, including afterload reduction and attenuation of nitrate tolerance, have also been observed with angiotensin-converting enzyme inhibitors. Demonstrating similar clinical benefits with nitrates plus angiotensin-converting enzyme inhibitor therapy alone, in the absence of hydralazine, may represent an opportunity to improve heart failure care by increasing the use of nitrates. In this paper, we summarize data that support studying such an approach. (c) 2013 by the American College of Cardiology Foundation

引用

页码：183 / 191

页数：9

共 80 条

[31] Chronic ACE inhibition enhances the endothelial control of arterial mechanics and flow-dependent vasodilatation in heart failure
Joannides, R
Bizet-Nafeh, C
Costentin, A
Iacob, M
Derumeaux, G
Cribier, A
Thuillez, C
[J]. HYPERTENSION, 2001, 38 (06) : 1446 - 1450
[32] DOSE REQUIREMENTS AND HEMODYNAMIC-EFFECTS OF TRANSDERMAL NITROGLYCERIN COMPARED WITH PLACEBO IN PATIENTS WITH CONGESTIVE HEART-FAILURE
JORDAN, RA
SETH, L
HENRY, DA
WILEN, MM
FRANCIOSA, JA
[J]. CIRCULATION, 1985, 71 (05) : 980 - 986
[33] RAPIDLY DEVELOPING TOLERANCE TO TRANSDERMAL NITROGLYCERIN IN CONGESTIVE-HEART-FAILURE
JORDAN, RA
SETH, L
CASEBOLT, P
HAYES, MJ
WILEN, MM
FRANCIOSA, J
[J]. ANNALS OF INTERNAL MEDICINE, 1986, 104 (03) : 295 - 298
[34] Race-specific differences in endothelial function - Predisposition of African Americans to vascular diseases
Kalinowski, L
Dobrucki, IT
Malinski, T
[J]. CIRCULATION, 2004, 109 (21) : 2511 - 2517
[35] PREVENTION OF NITRATE TOLERANCE WITH ANGIOTENSION CONVERTING ENZYME-INHIBITORS
KATZ, RJ
LEVY, WS
BUFF, L
WASSERMAN, AG
[J]. CIRCULATION, 1991, 83 (04) : 1271 - 1277
[36] Mechanisms and implications of endothelial dysfunction in congestive heart failure
Katz, SD
[J]. CURRENT OPINION IN CARDIOLOGY, 1997, 12 (03) : 259 - 264
[37] Increased oxidative stress in patients with congestive heart failure
Keith, M
Geranmayegan, A
Sole, MJ
Kurian, R
Robinson, A
Omran, AS
Jeejeebhoy, KN
[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1998, 31 (06) : 1352 - 1356
[38] Evidence for a causal role of the renin-angiotensin system in nitrate tolerance
Kurz, S
Hink, U
Nickenig, G
Borthayre, AB
Harrison, DG
Münzel, T
[J]. CIRCULATION, 1999, 99 (24) : 3181 - 3187
[39] IMPROVED EXERCISE CAPACITY AND DIFFERING ARTERIAL AND VENOUS TOLERANCE DURING CHRONIC ISOSORBIDE DINITRATE THERAPY FOR CONGESTIVE HEART-FAILURE
LEIER, CV
HUSS, P
MAGORIEN, RD
UNVERFERTH, DV
[J]. CIRCULATION, 1983, 67 (04) : 817 - 822
[40] ATTENUATION OF MYOCARDIAL REPERFUSION INJURY BY SULFHYDRYL-CONTAINING ANGIOTENSIN CONVERTING ENZYME-INHIBITORS
LIU, XK
ENGELMAN, RM
ROUSOU, JA
CORDIS, GA
DAS, DK
[J]. CARDIOVASCULAR DRUGS AND THERAPY, 1992, 6 (04) : 437 - 443

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