A Facile Electrochemical Strategy for the Azidation of Benzylic C(sp3)-H Bonds

被引：8
作者：
He, Guoxue [1 ,2 ]
Li, Yutian [1 ,2 ]
Zhou, Shengbin [1 ,2 ]
Yang, Xiaohao [1 ,2 ]
Shang, Aolong [1 ,2 ]
Wang, Yunbo [1 ,2 ]
Liu, Hong [1 ,2 ,3 ]
Zhou, Yu [1 ,2 ,3 ]
机构：
[1] UCAS, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 2022卷 / 44期
基金：
中国国家自然科学基金;
关键词：
Azidation; Benzyl; C-N bonds; C(sp(3))-H; Electrochemistry; METAL-CATALYZED AZIDATION; C-H BONDS; CLICK CHEMISTRY; COUPLING REACTIONS; AMINATION; AZOLES; FUNCTIONALIZATION; CYCLOADDITION; SUBSTITUTION; DIVERSITY;
D O I：
10.1002/ejoc.202201041
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report a direct azidation of benzylic C(sp(3))-H bonds via an electrochemical process, which use cheap and durable graphite plates as electrodes, without any external oxidants or metal catalysts. This protocol is a novel, green and environmentally benign synthetic strategy to achieve azidation of C(sp(3))-H in benzylic group. More importantly, these azidation products are suitable for late-stage functionalization to afford diversified triazole and tetrazole derivatives.
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页数：4
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