The molecular genetics of the melanocortin pathway and energy homeostasis

被引:8
作者
Leibel, RL
机构
[1] Columbia Univ, Div Mol Genet, New York, NY 10032 USA
[2] Columbia Univ, Naomi Berrie Diabet Ctr, New York, NY 10032 USA
关键词
D O I
10.1016/j.cmet.2006.01.010
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:79 / 81
页数:3
相关论文
共 10 条
[1]   A role for β-melanocyte-stimulating hormone in human body-weight regulation [J].
Biebermann, H ;
Castañeda, TR ;
van Landeghem, F ;
von Deimling, A ;
Escher, F ;
Brabant, G ;
Hebebrand, J ;
Hinney, A ;
Tschöp, MH ;
Grüters, A ;
Krude, H .
CELL METABOLISM, 2006, 3 (02) :141-146
[2]   A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism [J].
Challis, BG ;
Pritchard, LE ;
Creemers, JWM ;
Delplanque, J ;
Keogh, JM ;
Luan, J ;
Wareham, NJ ;
Yeo, GSH ;
Bhattacharyya, S ;
Froguel, P ;
White, A ;
Farooqi, IS ;
O'Rahilly, S .
HUMAN MOLECULAR GENETICS, 2002, 11 (17) :1997-2004
[3]   Anatomy and regulation of the central melanocortin system [J].
Cone, RD .
NATURE NEUROSCIENCE, 2005, 8 (05) :571-578
[4]   Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene [J].
Farooqi, IS ;
Keogh, JM ;
Yeo, GSH ;
Lank, EJ ;
Cheetham, T ;
O'Rahilly, S .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (12) :1085-1095
[5]   Prevalence and trends in obesity among US adults, 1999-2000 [J].
Flegal, KM ;
Carroll, MD ;
Ogden, CL ;
Johnson, CL .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (14) :1723-1727
[6]   Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans [J].
Krude, H ;
Biebermann, H ;
Luck, W ;
Horn, R ;
Brabant, G ;
Grüters, A .
NATURE GENETICS, 1998, 19 (02) :155-157
[7]   A POMC variant implicates β-melanocyte-stimulating hormone in the control of human energy balance [J].
Lee, YS ;
Challis, BG ;
Thompson, DA ;
Yeo, GSH ;
Keogh, JM ;
Madonna, ME ;
Wraight, V ;
Sims, M ;
Vatin, V ;
Meyre, D ;
Shield, J ;
Burren, C ;
Ibrahim, Z ;
Cheetham, T ;
Swift, P ;
Blackwood, A ;
Hung, CCC ;
Wareham, NJ ;
Froguel, P ;
Millhauser, GL ;
O'Rahilly, S ;
Farooqi, IS .
CELL METABOLISM, 2006, 3 (02) :135-140
[8]   Genetic and environmental factors in relative body weight and human adiposity [J].
Maes, HHM ;
Neale, MC ;
Eaves, LJ .
BEHAVIOR GENETICS, 1997, 27 (04) :325-351
[9]  
SEIDAH NG, 1994, METHOD ENZYMOL, V244, P175
[10]  
STE ML, 2000, P NATL ACAD SCI USA, V97, P12339