Nanoemulsions as Delivery Systems for Lipophilic Drugs

被引:50
作者
de Compos, Vania E. B. [1 ]
Ricci-Junior, Eduardo [2 ]
Mansur, Claudia R. E. [1 ]
机构
[1] Univ Fed Rio de Janeiro, Inst Macromol, Ctr Technol, Ilha Fundao,BJ, BR-21945970 Rio De Janeiro, Brazil
[2] Univ Fed Rio de Janeiro, Fac Pharm, Dept Med, Lab Desenvolvimento Galenico LADEG,Ilha Fundao, BR-21941590 Rio De Janeiro, Brazil
关键词
Nanoemulsions; Drug Delivery; Methods; ENERGY EMULSIFICATION METHODS; W/O NANO-EMULSIONS; IN-VITRO; CATIONIC NANOEMULSIONS; SUBMICRON EMULSIONS; PLGA NANOPARTICLES; FORMULATION; OIL; PACLITAXEL; SIZE;
D O I
10.1166/jnn.2012.5690
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Nanoemulsions have received a growing attention as colloidal drug carriers for pharmaceutical applications. Their advantages over conventional formulations include drug enhanced solubility and bioavailability, protection from toxicity, improved pharmacological activity and stability, more sustained delivery and protection from physical and chemical degradation. Nanoemulsions can be prepared by two major techniques, high-energy and low-energy emulsification. Both these emulsification methods have proved to be efficient to obtain stable nanoemulsions with small and highly uniform droplets. Further research into nanoemulsions is important to develop novel liquid formulations with more efficient results in therapeutic.
引用
收藏
页码:2881 / 2890
页数:10
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