Antiangiogenic Activity of Mononuclear Copper(II) Polypyridyl Complexes for the Treatment of Cancers

被引：99

作者：

Nagababu, Penumaka ^{[1
]}

Barui, Ayan Kumar ^{[2
,5
]}

Thulasiram, Bathini ^{[1
]}

Devi, C. Shobha ^{[3
]}

Satyanarayana, S. ^{[4
]}

Patra, Chitta Ranjan ^{[2
,5
]}

Sreedhar, Bojja ^{[1
,5
]}

机构：

[1] Indian Inst Chem Technol, CSIR, Inorgan & Phys Chem Div, Hyderabad 500007, Telangana State, India

[2] Indian Inst Chem Technol, CSIR, Biomat Grp, Hyderabad 500007, Telangana State, India

[3] Natl Dong Hwa Univ, Dept Chem, Hualien, Taiwan

[4] Osmania Univ, Dept Chem, Hyderabad 500007, Telangana State, India

[5] Acad Sci & Innovat Res AcSIR, New Delhi 600113, India

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2015年 / 58卷 / 13期

关键词：

DNA CLEAVAGE; IN-VITRO; DEOXYRIBONUCLEIC-ACID; ANTICANCER ACTIVITY; FLUORESCENT-PROBES; REACTIVE OXYGEN; BINDING; APOPTOSIS; LIGAND; CELLS;

D O I：

10.1021/acs.jmedchem.5b00651

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of four new mononuclear copper(II) polypyridyl complexes (1-4) have been designed, developed, and thoroughly characterized by several physicochemical techniques. The CT-DNA binding properties of 1-4 have been investigated by absorption, emission spectroscopy, and viscosity measurements. All the complexes especially 1 and 4 exhibit cytotoxicity toward several cancer cell lines, suggesting their anticancer properties as observed by several in vitro assays. Additionally, the complexes show inhibition of endothelial cell (HUVECs) proliferation, indicating their antiangiogenic nature. In vivo chick embryo angiogenesis assay again confirms the antiangiogenic properties of 1 and 4. The formation of excessive intracellular ROS (H2O2 and O-2(center dot-))) and upregulation of BAX induced by copper(II) complexes may be the plausible mechanisms behind their anticancer activities. The present study may offer a basis for the development of new transition metal complexes through suitable choice of ligands for cancer therapeutics by controlling tumor angiogenesis.

引用

页码：5226 / 5241

页数：16

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