Protein tyrosine phosphatase 1B inhibitors from natural sources

被引：66

作者：

Zhao, Bing Tian ^{[1
,2
]}

Duc Hung Nguyen ^{[1
]}

Le, Duc Dat ^{[1
]}

Choi, Jae Sue ^{[3
]}

Min, Byung Sun ^{[1
]}

Woo, Mi Hee ^{[1
]}

机构：

[1] Daegu Catholic Univ, Drug Res & Dev Ctr, Coll Pharm, Gyongsan 38430, South Korea

[2] Jiangnan Univ, Sch Chem & Mat Engn, Wuxi 214122, Peoples R China

[3] Pukyong Natl Univ, Dept Food Sci & Nutr, Busan 48513, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2018年 / 41卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

PTP1B inhibitors; Natural sources; Chemical structure; Structure-activity relationships; POLYUNSATURATED FATTY-ACIDS; STIMULATES GLUCOSE-UPTAKE; ANTI-ALZHEIMERS DISEASE; EDIBLE BROWN-ALGAE; ALPHA-GLUCOSIDASE; PTP1B INHIBITORS; STEM-BARK; AERIAL PARTS; A-C; ISOPRENYLATED FLAVONOIDS;

D O I：

10.1007/s12272-017-0997-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Since PTP1B enzyme was discovered in 1988, it has captured the research community's attention. This landmark discovery has stimulated numerous research studies on a variety of human diseases, including cancer, inflammation, and diabetes. Tremendous progress has been made in finding PTP1B inhibitors and exploring PTP1B regulatory mechanisms. This review investigates for the natural PTP1B inhibitors, and focuses on the common characteristics of the discovered structures and structure-activity relationships. To facilitate understanding, all the natural compounds are here divided into five different classes (fatty acids, phenolics, terpenoids, steroids, and alkaloids), according to their skeletons. These PTP1B inhibitors of scaffold structures could serve as a theoretical basis for new concept drug discovery and design.

引用

页码：130 / 161

页数：32

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