Activity of Imipenem with Relebactam against Gram-Negative Pathogens from New York City

被引：169

作者：

Lapuebla, Amabel ^{[1
]}

Abdallah, Marie ^{[1
]}

Olafisoye, Olawole ^{[1
]}

Cortes, Christopher ^{[2
]}

Urban, Carl ^{[2
]}

Landman, David ^{[1
]}

Quale, John ^{[1
]}

机构：

[1] Suny Downstate Med Ctr, Div Infect Dis, Brooklyn, NY 11203 USA

[2] New York Hosp Queens, James J Rahal Jr Div Infect Dis, Flushing, NY USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 08期

关键词：

KLEBSIELLA-PNEUMONIAE; ANTIMICROBIAL RESISTANCE; PSEUDOMONAS-AERUGINOSA; LACTAMASE INHIBITOR; CARBAPENEMASES; ACINETOBACTER; EXPRESSION; BACTERIA; MK-7655;

D O I：

10.1128/AAC.00830-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Imipenem with relebactam was active against Escherichia coli, Klebsiella pneumoniae, and Enterobacter spp., including K. pneumoniae carbapenemase (KPC)-producing isolates. Loss of OmpK36 in KPC-producing K. pneumoniae isolates affected the susceptibility of this combination. Enhanced activity was evident against Pseudomonas aeruginosa, including isolates with depressed oprD and increased ampC expression. However, the addition of relebactam to imipenem did not provide added benefit against Acinetobacter baumannii. The combination of imipenem with relebactam demonstrated activity against KPC-producing Enterobacteriaceae and multidrug-resistant P. aeruginosa.

引用

页码：5029 / 5031

页数：3

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