Synthesis and antiproliferative evaluation of novel 5-(4-methylpiperazin-1-yl)-2-phenyl-1H-benzimidazole derivatives

被引：4

作者：

Alp, Mehmet ^{[1
]}

Gurkan-Alp, A. Selen ^{[1
]}

Ozkan, Tulin ^{[2
]}

Sunguroglu, Asuman ^{[2
]}

机构：

[1] Ankara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey

[2] Ankara Univ, Fac Pharm, Dept Med Biol, TR-06100 Ankara, Turkey

来源：

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES | 2015年 / 70卷 / 3-4期

关键词：

AML; antiproliferative activity; apoptosis; benzimidazole; HL-60; BIOLOGICAL EVALUATION; APOPTOSIS; CELLS; ASSAY;

D O I：

10.1515/znc-2014-4189

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of novel 5-(4-methylpiperazin-1-yl)-2-phenyl-1H-benzimidazoles (5-14) were synthesized and evaluated for their in vitro antiproliferative activities against the human leukemia cell line HL-60. Compounds 5-7 and 10-12 exhibited potent antiproliferative activities against this cell line. The quantitative analysis of apoptosis by flow cytometry demonstrated that the percentages of apoptotic HL-60 cells treated with compounds 5 and 10-12 were significantly higher than in the control.

引用

页码：79 / 85

页数：7

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