(1R,3S)-3-(1H-Benzo[d]imidazol-2-yl)-1,2,2-tri-methylcyclopentane-1-carboxylic acid as a new anti-diabetic active pharmaceutical ingredient

被引：1

作者：

Kovalenko, Sergiy M. ^{[1
]}

Konovalova, Irina S. ^{[2
]}

Merzlikin, Sergiy, I ^{[3
]}

Chuev, Vladimir P. ^{[4
,5
]}

Kravchenko, Dmitry, V ^{[6
]}

机构：

[1] Kharkov Natl Univ, 4 Svobody Sq, UA-61077 Kharkiv, Ukraine

[2] Natl Acad Sci Ukraine, State Sci Inst Inst Single Crystals, UA-61001 Kharkov, Ukraine

[3] Natl Univ Pharm, 53 Pushkinska St, UA-61002 Kharkiv, Ukraine

[4] Belgorod State Univ, Fed State Autonomous Educ Inst Higher Educ, 85 Pobedy St, Belgorod 308015, Russia

[5] Expt Plant Dent Mat Vladmiva, 81d Michurin St, Belgorod 308015, Russia

[6] Chem Divers Res Inst, 2A Rabochaya St, Chimki 141400, Moscow Region, Russia

来源：

ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS | 2020年 / 76卷

关键词：

crystal structure; Hirshfeld surface; 1H-benzo[d]imidazol-2-yl-1,2,2-trimethylcyclopentane-carboxylic; acid; active pharmaceutical; ingredient; anti-diabetic agents; type; 2; diabetes;

D O I：

10.1107/S2056989020010439

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

The chiral title compound, C16H20N2O2, which can be used for producing active pharmaceutical ingredients for treatment of type 2 pancreatic diabetes and other pathologies dependent on insulin resistance, was prepared from (1R,3S)-camphoric acid and o-phenylenediamine. It crystallized from an ethanol solution in the chiral monoclinic P2(1) space group. The five-membered ring adopts a twisted conformation with the methyl-substituted C atoms displaced by -0.273 (5) and 0.407 (5) angstrom from the mean plane through the other three atoms. In the crystal, molecules are linked by O-H center dot center dot center dot N hydrogen bonds, forming chains along the a-axis direction. Hirshfeld surface analysis and two-dimensional fingerprint plots were used to analyze the intermolecular contacts present in the crystal.

引用

页码：1407 / +

页数：10

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