Natural (-)-Vasicine as a Novel Source of Optically Pure 1-Benzylpyrrolidin-3-ol

被引：15

作者：

Aga, Mushtaq A. ^{[1
]}

Kumar, Brijesh ^{[1
]}

Rouf, Abdul ^{[1
]}

Shah, Bhahwal A. ^{[1
]}

Andotra, Samar S. ^{[1
]}

Taneja, Subhash C. ^{[1
]}

机构：

[1] Indian Inst Integrat Med, Bioorgan Chem Div, Jammu 180001, Jammu & Kashmir, India

来源：

HELVETICA CHIMICA ACTA | 2013年 / 96卷 / 05期

关键词：

Adhatoda vasica; ()-Vasicine; Pyrrolidin-3-ol; ADHATODA-VASICA; PHOSPHORIC-ACID; CARBAPENEM; ALKALOIDS; 3-HYDROXYPYRROLIDINES; PYRROLIDINES; DERIVATIVES; ESTERS;

D O I：

10.1002/hlca.201200307

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile and scalable methodology for the preparation of optically active (3S)-1-benzylpyrrolidin-3-ol (3), an important drug precursor, is reported. Starting from the naturally occurring alkaloid ()-vasicine (1), a major alkaloid of the plant Adhatoda vasica, 3 was obtained in 84% overall yield (Scheme3).

引用

页码：969 / 977

页数：9

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