No Significant Association Between Genetic Variants in 7 Candidate Genes and Response to Methylphenidate Treatment in Adult Patients With ADHD

被引：32

作者：

Contini, Veronica ^{[1
]}

Victor, Marcelo M. ^{[2
]}

Bertuzzi, Guilherme P. ^{[1
]}

Salgado, Carlos A. I. ^{[2
]}

Picon, Felipe A. ^{[2
]}

Grevet, Eugenio H. ^{[2
]}

Rohde, Luis A. ^{[2
,3
]}

Belmonte-de-Abreu, Paulo ^{[2
,3
]}

Bau, Claiton H. D. ^{[1
,2
]}

机构：

[1] Univ Fed Rio Grande do Sul, Inst Biociencias, Dept Genet, BR-91501970 Porto Alegre, RS, Brazil

[2] Hosp Clin Porto Alegre, Adult ADHD Outpatient Clin, Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande do Sul, Fac Med, Dept Psychiat, Porto Alegre, RS, Brazil

来源：

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY | 2012年 / 32卷 / 06期

关键词：

attention-deficit/hyperactivity disorder; pharmacogenetics; methylphenidate; serotonin; dopamine; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; POLYMORPHISM; SAMPLE; DAT1; PHARMACOGENETICS; CHILDREN;

D O I：

10.1097/JCP.0b013e318270e727

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Results from pharmacogenetic investigations of methylphenidate (MPH) response in patients with ADHD are still inconsistent, especially among adults. This study investigates the role of genetic variants (SLC6A4, HTR1B, TPH2, DBH, DRD4, COMT, and SNAP25) in the response to MPH in a sample of 164 adults. Genes were chosen owing to previous evidence for an influence in ADHD susceptibility. No significant differences in allele or genotype frequencies between MPH responders and nonresponders were detected. In conclusion, our findings do not support an effect of these genes in the pharmacogenetics of MPH among adults with ADHD.

引用

页码：820 / 823

页数：4

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