Multispectroscopic DNA interaction and Docking studies

被引：9
|
作者：
Shekhar, B. [1 ,2 ]
Vasantha, P. [1 ]
Kumar, B. Sathish [1 ,2 ]
Lakshmi, P. V. Anantha [2 ,3 ]
机构：
[1] Osmania Univ, Univ Coll Women, Dept Chem, Hyderabad 500095, Telangana State, India
[2] Osmania Univ, Dept Chem, Hyderabad 500007, Telangana State, India
[3] Osmania Univ, Univ Coll Technol, Dept Chem, Hyderabad 500007, Telangana State, India
来源：
APPLIED ORGANOMETALLIC CHEMISTRY | 2018年 / 32卷 / 04期
关键词：
DNA; docking; groove binding metformin; oxovanadium(IV); APOPTOSIS-INDUCING ACTIVITY; LIGHT SWITCH COMPLEXES; SCHIFF-BASE COMPLEXES; OXOVANADIUM(IV) COMPLEXES; MOLECULAR DOCKING; ANTIMICROBIAL ACTIVITY; ANTICANCER ACTIVITIES; ANTIDIABETIC DRUG; BINDING; PHOTOCLEAVAGE;
D O I：
10.1002/aoc.4254
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Two new water soluble oxovanadium(IV) complexes with formulae Na[VO(his)(met)SO4] (1) and Na[VO(gly)(met)SO4] (2), (gly=glycine his=histidine, and met=metformin) were synthesized and characterized by LCMS, UV-Visible absorption, infrared spectra, magnetic moment, elemental analysis, thermal analysis and electronic spectral studies. The metal center was found in an octahedral geometry. DNA binding interaction of these complexes with CT DNA has been explored by UV-Visible absorption, fluorescence, viscosity measurements and cleavage studies. Finally the binding of the complexes with CT-DNA could be surface binding, mainly in the groove binding. The complexes were docked in to B-DNA sequence, 5'(D*AP*CP*CP*GP*AP*CP*GP*TP*CP*GP*GP*T)-3' retrieved from protein data bank (PDB ID: 423D), using Discovery Studio 2.1 software.
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页数：11
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