LlS1 - no more no less

被引：21
作者：
Reiner, O [1 ]
Cahana, A
Escamez, T
Martinez, S
机构：
[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel
[2] CSIC UMH, Inst Neurociencias, San Juan De Alicante, Spain
来源：
MOLECULAR PSYCHIATRY | 2002年 / 7卷 / 01期
关键词：
D O I：
10.1038/sj/mp/4000975
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
LIS1 is one of the genes that has a principle role in brain development since hemizygote mutations in LIS1 result in a severe brain malformation known as lissencephaly ('smooth brain'). LIS1 is a WD repeat protein and is known to be involved in several protein complexes that are likely to play a functional role in brain development. We discuss here the brain developmental phenotype observed in mice heterozygote for an N-terminal truncated LIS1 protein in view of known LIS1 protein interactions.
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页码：12 / 16
页数：5
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