Epigenetic Control of Reprogramming and Transdifferentiation by Histone Modifications

被引：26
|
作者：
Qin, Hua [1 ]
Zhao, Andong [1 ]
Zhang, Cuiping [2 ]
Fu, Xiaobing [2 ]
机构：
[1] Tianjin Med Univ, Tianjin 300070, Peoples R China
[2] Peoples Liberat Army Gen Hosp, Hosp Affiliated 1, Key Lab Wound Repair & Regenerat PLA, 51 Fu Cheng Rd, Beijing, Peoples R China
来源：
STEM CELL REVIEWS AND REPORTS | 2016年 / 12卷 / 06期
关键词：
Somatic cells; iPSCs; Reprogramming; Transdifferentiation; Histone modifications; Epigenetic; Cell fate conversion; PLURIPOTENT STEM-CELLS; PIONEER TRANSCRIPTION FACTORS; SMALL-MOLECULE; MOUSE FIBROBLASTS; SOMATIC-CELLS; DIRECT CONVERSION; PROGENITOR CELLS; NEURONAL CELLS; EXPRESSION; GENERATION;
D O I：
10.1007/s12015-016-9682-4
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Somatic cells can be reprogrammed to pluripotent stem cells or transdifferentiate to another lineage cell type. Much efforts have been made to unravel the epigenetic mechanisms underlying the cell fate conversion. Histone modifications as the major epigenetic regulator are implicated in various aspects of reprogramming and transdifferentiation. Here, we discuss the roles of histone modifications on reprogramming and transdifferentiation and hopefully provide new insights into induction and promotion of the cell fate conversion by modulating histone modifications.
引用
收藏
页码：708 / 720
页数：13
相关论文
共 50 条
  • [1] Epigenetic Control of Reprogramming and Transdifferentiation by Histone Modifications
    Hua Qin
    Andong Zhao
    Cuiping Zhang
    Xiaobing Fu
    Stem Cell Reviews and Reports, 2016, 12 : 708 - 720
  • [2] Resetting Epigenetic Memory by Reprogramming of Histone Modifications in Mammals
    Zheng, Hui
    Huang, Bo
    Zhang, Bingjie
    Xiang, Yunlong
    Du, Zhenhai
    Xu, Qianhua
    Li, Yuanyuan
    Wang, Qiujun
    Ma, Jing
    Peng, Xu
    Xu, Feng
    Xie, Wei
    MOLECULAR CELL, 2016, 63 (06) : 1066 - 1079
  • [3] Reprogramming, oscillations and transdifferentiation in epigenetic landscapes
    Kaity, Bivash
    Sarkar, Ratan
    Chakrabarti, Buddhapriya
    Mitra, Mithun K.
    SCIENTIFIC REPORTS, 2018, 8
  • [4] Reprogramming, oscillations and transdifferentiation in epigenetic landscapes
    Bivash Kaity
    Ratan Sarkar
    Buddhapriya Chakrabarti
    Mithun K. Mitra
    Scientific Reports, 8
  • [5] Epigenetic Regulation of B Lymphocyte Differentiation, Transdifferentiation, and Reprogramming
    Barneda-Zahonero, Bruna
    Roman-Gonzalez, Lidia
    Collazo, Olga
    Mahmoudi, Tokameh
    Parra, Maribel
    COMPARATIVE AND FUNCTIONAL GENOMICS, 2012,
  • [6] Epigenetic control of ovarian function: The emerging role of histone modifications
    LaVoie, HA
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2005, 243 (1-2) : 12 - 18
  • [7] PiRNAs link epigenetic modifications to reprogramming
    Wang, Yin
    Sun, Teng
    Wang, Kun
    Wang, Jian-Xun
    Li, Pei-Feng
    HISTOLOGY AND HISTOPATHOLOGY, 2014, 29 (12) : 1489 - 1497
  • [8] EPIGENETIC CONTROL THROUGH HISTONE MODIFICATIONS REGULATES MACROPHAGES DURING ATHEROSCLEROSIS
    Neele, A. E.
    Van den Bossche, J.
    Hoeksema, M. A.
    de Winther, M. P. J.
    ATHEROSCLEROSIS, 2014, 235 (02) : E130 - E130
  • [9] Metabolic reprogramming and epigenetic modifications on the path to cancer
    Sun, Linchong
    Zhang, Huafeng
    Gao, Ping
    PROTEIN & CELL, 2022, 13 (12) : 877 - 919
  • [10] Metabolic reprogramming and epigenetic modifications on the path to cancer
    Linchong Sun
    Huafeng Zhang
    Ping Gao
    Protein & Cell, 2022, 13 (12) : 877 - 919
12345