Substituted hydroxyapatites for biomedical applications: A review

被引：592

作者：

Supova, Monika ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Rock Struct & Mech, Dept Composites & Carbon Mat, Prague 18209, Czech Republic

来源：

CERAMICS INTERNATIONAL | 2015年 / 41卷 / 08期

关键词：

Bioapatite; Calcium phosphate; Hydroxyapatite; Substitution; SILVER-DOPED HYDROXYAPATITE; X-RAY-DIFFRACTION; MECHANOCHEMICAL-HYDROTHERMAL SYNTHESIS; CALCIUM-PHOSPHATE NANOPARTICLES; SOLUTION COMBUSTION SYNTHESIS; PROTEIN ADSORPTION PROPERTY; HUMAN OSTEOBLAST RESPONSE; PULSED-LASER DEPOSITION; IN-VITRO BIOACTIVITY; AB-INITIO SIMULATION;

D O I：

10.1016/j.ceramint.2015.03.316

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

This review summarizes recent and very recent work on preparing substituted hydroxyapatites. Ease of atomic doping or substitution in apatite opens this mineral up for a wide range of biomedical applications. It can be used for repairing and replacing diseased and damaged parts of musculoskeletal systems, and also as a drug or gene delivery agent, as a bioactive coating on metallic osseous implants, biomagnetic particles and fluorescent markers. First, the physicochemical properties of bioapatites are described and discussed. Then a general summary on substitution reaction for hydroxyapatite is made. Special attention is paid to describing anionic, cationic and multisubstituted hydroxyapatites used for various biomedical applications. Finally, conclusions are drawn and future perspectives are discussed. (C) 2015 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

引用

页码：9203 / 9231

页数：29

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