Xanthohumol, a prenylated chalcone from Humulus lupulus L., inhibits cholesteryl ester transfer protein

被引：42

作者：

Hirata, Hiroshi ^{[2
]}

Takazumi, Koji ^{[2
]}

Segawa, Shuichi ^{[2
]}

Okada, Yukio ^{[2
]}

Kobayashi, Naoyuki ^{[2
]}

Shigyo, Tatsuro ^{[2
]}

Chiba, Hitoshi ^{[1
]}

机构：

[1] Hokkaido Univ, Sch Med, Fac Hlth Sci, Kita Ku, Sapporo, Hokkaido 0600812, Japan

[2] Sapporo Breweries Ltd, Frontier Labs Value Creat, Shizuoka 4250013, Japan

来源：

FOOD CHEMISTRY | 2012年 / 134卷 / 03期

关键词：

Xanthohumol; Cholesteryl ester transfer protein; Chalcone; Prenyl group; Hop; HIGH-DENSITY-LIPOPROTEIN; LIPID TRANSFER PROTEIN; CARDIOVASCULAR EVENTS; HDL CHOLESTEROL; LDL; ATHEROSCLEROSIS; POLYPHENOLS; DEFICIENCY; METABOLISM; STATINS;

D O I：

10.1016/j.foodchem.2012.03.043

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

High density lipoprotein (HDL)-cholesterol levels are correlated with a low risk of atherosclerosis. The inhibition of cholesteryl ester transfer protein (CETP), which catalyses cholesterol transfer between lipoproteins, leads to an increase in HDL-cholesterol and is expected to be the next anti-atherogenic target. This study revealed that xanthohumol, a prenylated chalcone, showed the highest inhibition against CETP from screening of natural products in various plants. We investigated the inhibitory activity of some chalcones and flavanones. Naringenin chalcone showed weak CETP inhibition compared with xanthohumol. In addition, isoxanthohumol and naringenin drastically decreased the inhibitory activity. These results suggest that the prenyl group and chalcone structure of xanthohumol were responsible for the CETP inhibitory activity. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1432 / 1437

页数：6

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