Celastrol Inhibits the Growth of Ovarian Cancer Cells in vitro and in vivo

被引：41
|
作者：
Xu, Li-Na [1 ]
Zhao, Na [1 ]
Chen, Jin-Yan [2 ]
Ye, Piao-Piao [1 ]
Nan, Xing-Wei [1 ]
Zhou, Hai-Hong [1 ]
Jiang, Qi-Wei [3 ,4 ]
Yang, Yang [3 ,4 ]
Huang, Jia-Rong [3 ,4 ]
Yuan, Meng-Ling [3 ,4 ]
Xing, Zi-Hao [3 ,4 ]
Wei, Meng-Ning [3 ,4 ]
Li, Yao [3 ,4 ]
Shi, Zhi [3 ,4 ]
Yan, Xiao-Jian [1 ,5 ,6 ]
机构：
[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Gynecol, Wenzhou, Peoples R China
[2] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Gynecol, Hangzhou, Zhejiang, Peoples R China
[3] Jinan Univ, Coll Life Sci & Technol, Guangdong Prov Key Lab Bioengn Med, Dept Cell Biol,Natl Engn Res Ctr Genet Med, Guangzhou, Guangdong, Peoples R China
[4] Jinan Univ, Coll Life Sci & Technol, Guangdong Prov Key Lab Bioengn Med, Inst Biomed,Natl Engn Res Ctr Genet Med, Guangzhou, Guangdong, Peoples R China
[5] Zhejiang Univ, Sch Med, Womens Hosp, Ctr Uterine Canc Diag & Therapy Res Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China
[6] Zhejiang Univ, Sch Med, Inst Translat Med, Hangzhou, Zhejiang, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2019年 / 9卷
基金：
中国国家自然科学基金;
关键词：
celastrol; reactive oxygen species; N-acetyl-cysteine; apoptosis; ovarian cancer; VOLASERTIB SUPPRESSES; MULTIDRUG-RESISTANCE; TRIPTOLIDE; MITOCHONDRIAL; CISPLATIN; ADENOCARCINOMA; ANTICANCER; ACTIVATION; EFFICACY; INVASION;
D O I：
10.3389/fonc.2019.00002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Celastrol is a natural triterpene isolated from the Chinese plant Thunder God Vine with potent antitumor activity. However, the effect of celastrol on the growth of ovarian cancer cells in vitro and in vivo is still unclear. In this study, we found that celastrol induced cell growth inhibition, cell cycle arrest in G2/M phase and apoptosis with the increased intracellular reactive oxygen species (ROS) accumulation in ovarian cancer cells. Pretreatment with ROS scavenger N-acetyl-cysteine totally blocked the apoptosis induced by celastrol. Additionally, celastrol inhibited the growth of ovarian cancer xenografts in nude mice. Altogether, these findings suggest celastrol is a potential therapeutic agent for treating ovarian cancer.
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页数：10
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