Role of Anti-Mullerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome

被引：57
作者：
Dewailly, Didier [1 ]
Barbotin, Anne-Laure [1 ,2 ]
Dumont, Agathe [3 ,4 ]
Catteau-Jonard, Sophie [1 ,3 ]
Robin, Geoffroy [3 ,4 ,5 ]
机构：
[1] Jean Pierre Aubert Res Ctr, Lab Dev & Plast Neuroendocrine Brain, Inserm, Lille, France
[2] CHU Lille, Hop Jeanne Flandre, Inst Biol Reprod Spermiol CECOS, Lille, France
[3] CHU Lille, Serv Gynecol Med Orthogenie & Sexol, Unite Fonct Gynecol Endocrinienne, Hop Jeanne Flandre, Lille, France
[4] CHU Lille, Serv Assistance Med Procreat & Preservat Fertil, Hop Jeanne Flandre, Lille, France
[5] Lille Univ, EA Gametogenesis & Gamete Qual 4308, Lille, France
来源：
FRONTIERS IN ENDOCRINOLOGY | 2020年 / 11卷
关键词：
anti-mullerian hormone; polycystic ovary syndrome; androgens; follicle; FSH; anovulation; GnRH; aromatase; GRANULOSA-CELLS; ANTIMULLERIAN HORMONE; LUTEINIZING-HORMONE; ANOVULATORY WOMEN; MLLERIAN HORMONE; ANTRAL FOLLICLE; LEVELS DECREASE; RECEPTOR; EXPRESSION; AMH;
D O I：
10.3389/fendo.2020.00641
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation of PCOS and 3- the role of AMH in the trans-generational transmission of PCOS. For each of those issues, the clinical and experimental evidences currently available are discussed and pathophysiological hypothesis are proposed.
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页数：9
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