Role of Anti-Mullerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome

被引：57
作者：
Dewailly, Didier [1 ]
Barbotin, Anne-Laure [1 ,2 ]
Dumont, Agathe [3 ,4 ]
Catteau-Jonard, Sophie [1 ,3 ]
Robin, Geoffroy [3 ,4 ,5 ]
机构：
[1] Jean Pierre Aubert Res Ctr, Lab Dev & Plast Neuroendocrine Brain, Inserm, Lille, France
[2] CHU Lille, Hop Jeanne Flandre, Inst Biol Reprod Spermiol CECOS, Lille, France
[3] CHU Lille, Serv Gynecol Med Orthogenie & Sexol, Unite Fonct Gynecol Endocrinienne, Hop Jeanne Flandre, Lille, France
[4] CHU Lille, Serv Assistance Med Procreat & Preservat Fertil, Hop Jeanne Flandre, Lille, France
[5] Lille Univ, EA Gametogenesis & Gamete Qual 4308, Lille, France
来源：
FRONTIERS IN ENDOCRINOLOGY | 2020年 / 11卷
关键词：
anti-mullerian hormone; polycystic ovary syndrome; androgens; follicle; FSH; anovulation; GnRH; aromatase; GRANULOSA-CELLS; ANTIMULLERIAN HORMONE; LUTEINIZING-HORMONE; ANOVULATORY WOMEN; MLLERIAN HORMONE; ANTRAL FOLLICLE; LEVELS DECREASE; RECEPTOR; EXPRESSION; AMH;
D O I：
10.3389/fendo.2020.00641
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation of PCOS and 3- the role of AMH in the trans-generational transmission of PCOS. For each of those issues, the clinical and experimental evidences currently available are discussed and pathophysiological hypothesis are proposed.
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页数：9
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共 69 条
[1]   Developmental origin of polycystic ovary syndrome - a hypothesis [J].
Abbott, DH ;
Dumesic, DA ;
Franks, S .
JOURNAL OF ENDOCRINOLOGY, 2002, 174 (01) :1-5
[2]   The phenotypic diversity in per-follicle anti-Mullerian hormone production in polycystic ovary syndrome [J].
Alebic, M. S. ;
Stojanovic, N. ;
Duhamel, A. ;
Dewailly, D. .
HUMAN REPRODUCTION, 2015, 30 (08) :1927-1933
[3]   Emerging Roles of Anti-Mullerian Hormone in Hypothalamic-Pituitary Function [J].
Barbotin, Anne-Laure ;
Peigne, Maeliss ;
Malone, Samuel Andrew ;
Giacobini, Paolo .
NEUROENDOCRINOLOGY, 2019, 109 (03) :218-229
[4]   Phenotypic variation in anti-Mullerian hormone (AMH) production per follicle in women with polycystic ovary syndrome (PCOS) and isolated polycystic ovarian morphology (PCOM): an observational cross-sectional study [J].
Bhide, Priya ;
Kulkarni, Abhijit ;
Dilgil, Merve ;
Dhir, Puja ;
Shah, Amit ;
Gudi, Anil ;
Homburg, Roy .
GYNECOLOGICAL ENDOCRINOLOGY, 2017, 33 (10) :801-806
[5]   Anti-Milllerian hormone and polycystic ovary syndrome [J].
Bhide, Priya ;
Homburg, Roy .
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY, 2016, 37 :38-45
[6]   Each small antral follicle in ovaries of women with polycystic ovary syndrome produces more antimullerian hormone than its counterpart in a normal ovary: an observational cross-sectional study [J].
Bhide, Priya ;
Dilgil, Merve ;
Gudi, Anil ;
Shah, Amit ;
Akwaa, Charity ;
Homburg, Roy .
FERTILITY AND STERILITY, 2015, 103 (02) :537-541
[7]   Anti-Mullerian hormone and ovarian dysfunction [J].
Broekmans, Frank J. ;
Visser, Jenny A. ;
Laven, Joop S. E. ;
Broer, Simone L. ;
Themmen, Axel P. N. ;
Fauser, Bart C. .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2008, 19 (09) :340-347
[8]   Anti-Mullerian Hormone and Ovarian Morphology in Women With Isolated Hypogonadotropic Hypogonadism/Kallmann Syndrome: Effects of Recombinant Human FSH [J].
Bry-Gauillard, Helene ;
Larrat-Ledoux, Florence ;
Levaillant, Jean-Marc ;
Massin, Nathalie ;
Maione, Luigi ;
Beau, Isabelle ;
Binart, Nadine ;
Chanson, Philippe ;
Brailly-Tabard, Sylvie ;
Hall, Janet E. ;
Young, Jacques .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2017, 102 (04) :1102-1111
[9]   Antimullerian hormone levels decrease in female-to-male transsexuals using testosterone as cross-sex therapy [J].
Caanen, Mirte R. ;
Soleman, Remi S. ;
Kuijper, Esther A. M. ;
Kreukels, Baudewijntje P. C. ;
De Roo, Chloe ;
Tilleman, Kelly ;
De Sutter, Petra ;
van Trotsenburg, Mick A. A. ;
Broekmans, Frank J. ;
Lambalk, Cornelis B. .
FERTILITY AND STERILITY, 2015, 103 (05) :1340-1345
[10]   Polycystic ovaries at ultrasound: normal variant or silent polycystic ovary syndrome? [J].
Catteau-Jonard, S. ;
Bancquart, J. ;
Poncelet, E. ;
Lefebvre-Maunoury, C. ;
Robin, G. ;
Dewailly, D. .
ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2012, 40 (02) :223-229
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