Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease

被引：285

作者：

Ferreira, Sergio T. ^{[1
]}

Clarke, Julia R. ^{[1
]}

Bomfim, Theresa R. ^{[1
]}

De Felice, Fernanda G. ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, Rio De Janeiro, Brazil

来源：

ALZHEIMERS & DEMENTIA | 2014年 / 10卷

关键词：

Inflammation; Alzheimer's disease; Diabetes; Obesity; Insulin signaling; Aging; NECROSIS-FACTOR-ALPHA; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ENDOPLASMIC-RETICULUM STRESS; TRANSGENIC MOUSE MODEL; ADIPOSE-TISSUE; TNF-ALPHA; PERISPINAL ETANERCEPT; COGNITIVE IMPROVEMENT; RECEPTOR SUBSTRATE-1; AMYLOID DEPOSITION;

D O I：

10.1016/j.jalz.2013.12.010

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A link between Alzheimer's disease (AD) and metabolic disorders has been established, with patients with type 2 diabetes at increased risk of developing AD and vice versa. The incidence of metabolic disorders, including insulin resistance and type 2 diabetes is increasing at alarming rates worldwide, primarily as a result of poor lifestyle habits. In parallel, as the world population ages, the prevalence of AD, the most common form of dementia in the elderly, also increases. In addition to their epidemiologic and clinical association, mounting recent evidence indicates shared mechanisms of pathogenesis between metabolic disorders and AD. We discuss the concept that peripheral and central nervous system inflammation link the pathogenesis of AD and metabolic diseases. We also explore the contribution of brain inflammation to defective insulin signaling and neuronal dysfunction. Last, we review recent evidence indicating that targeting neuroinflammation may provide novel therapeutic avenues for AD. (C) 2014 The Alzheimer's Association. All rights reserved.

引用

页码：S76 / S83

页数：8

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