Concept for a gas-cell-driven drug delivery system for therapeutic applications

被引：3

作者：

Becker, S. ^{[1
]}

Xu, T. ^{[1
]}

Ilchmann, F. ^{[1
]}

Eisler, J. ^{[1
]}

Wolf, B. ^{[1
]}

机构：

[1] Tech Univ Munich, Heinz Nixdorf Lehrstuhl Med Elekt, Munich, Germany

来源：

PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE | 2011年 / 225卷 / H12期

关键词：

implantable pump; drug delivery device; gas cell;

D O I：

10.1177/0954411911423348

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This paper presents a concept for an implantable micro-pump based on hydrogen-generating gas cells. The gas-generating cell is separated from the drug reservoir by an expandable latex membrane. The system offers linear drug delivery with flowrates ranging from 8 nl/s to 2 mu l/s and a total delivery volume of up to 160 ml. Drugs can be dispensed over a wide backpressure range. The device is scalable based on the size of the gas-producing cell and requires no external energy source. Possible fields of application include in vivo local drug delivery for chemotherapy, diabetes, and pain management.

引用

页码：1196 / 1201

页数：6

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