An efficient and high yield method for the N-tert-butoxycarbonyl protection of sterically hindered amino acids

被引：57

作者：

Khalil, EM ^{[1
]}

Subasinghe, NL ^{[1
]}

Johnson, RL ^{[1
]}

机构：

[1] UNIV MINNESOTA,DEPT MED CHEM,MINNEAPOLIS,MN 55455

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 20期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(96)00589-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved method for the N-tert-butoxycarbonyl protection of the amino functionality of alpha-alkylated prolines and other sterically hindered alpha,alpha-disubstituted amino acids has been developed in which the lipophilic base tetramethylammonium hydroxide is used to solubilize the otherwise insoluble zwitterionic amino acid in acetonitrile, thereby obviating the need for an aqueous medium. Copyright (C) 1996 Elsevier Science Ltd

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页码：3441 / 3444

页数：4

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