Diabetes and Altered Glucose Metabolism with Aging

被引：128

作者：

Kalyani, Rita Rastogi ^{[1
]}

Egan, Josephine M. ^{[2
]}

机构：

[1] Johns Hopkins Univ, Div Endocrinol & Metab, Dept Med, Sch Med, Baltimore, MD 21287 USA

[2] NIA, NIH, Baltimore, MD 21224 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2013年 / 42卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Diabetes; Aging; Insulin resistance; Beta-cell dysfunction; DEPENDENT INSULINOTROPIC POLYPEPTIDE; LOWER-EXTREMITY DISABILITY; EXAMINATION SURVEY NHANES; OLDER-ADULTS; MUSCLE STRENGTH; FUNCTIONAL DISABILITY; SKELETAL-MUSCLE; WOMENS HEALTH; MITOCHONDRIAL RESPIRATION; CARBOHYDRATE-METABOLISM;

D O I：

10.1016/j.ecl.2013.02.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetes and impaired glucose tolerance affect a substantial proportion of older adults. Abnormal glucose metabolism is not a necessary component of aging. Older adults with diabetes and altered glucose status likely represent a subset of the population at high risk for complications and adverse geriatric syndromes. Goals for treatment of diabetes in the elderly include control of hyperglycemia, prevention and treatment of diabetic complications, avoidance of hypoglycemia, and preservation of quality of life. Research exploring associations of dysglycemia and insulin resistance with the development of adverse outcomes in the elderly may ultimately inform use of future glucose-lowering therapies in this population.

引用

页码：333 / +

页数：16

共 104 条

[1] Muscle strength in type 2 diabetes [J].

Andersen, H ;

Nielsen, S ;

Mogensen, CE ;

Jakobsen, J .

DIABETES, 2004, 53 (06) :1543-1548

[2]

[Anonymous], 2012, DIABETES CARE, V35, pS11, DOI [10.2337/dc35-S011, 10.2337/dc12-s004]

[3]

[Anonymous], NEW ENGL J MED

[4] Phenotype of frailty: Characterization in the women's health and aging studies [J].

Bandeen-Roche, K ;

Xue, QL ;

Ferrucci, L ;

Walston, J ;

Guralnik, JM ;

Chaves, P ;

Zeger, SL ;

Fried, LP .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2006, 61 (03) :262-266

[5] Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons [J].

Barbieri, M ;

Ferrucci, L ;

Ragno, E ;

Corsi, A ;

Bandinelli, S ;

Bonafè, M ;

Olivieri, F ;

Giovagnetti, S ;

Franceschi, C ;

Guralnik, JM ;

Paolisso, G .

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2003, 284 (03) :E481-E487

[6] Age-related insulin resistance: is it an obligatory finding? The Lesson from healthy centenarians [J].

Barbieri, M ;

Rizzo, MR ;

Manzella, D ;

Paolisso, G .

DIABETES-METABOLISM RESEARCH AND REVIEWS, 2001, 17 (01) :19-26

[7] Insulin resistance and inflammation as precursors of frailty - The cardiovascular health study [J].

Barzilay, Joshua I. ;

Blaum, Caroline ;

Moore, Tisha ;

Xue, Qian Li ;

Hirsch, Calvin H. ;

Walston, Jeremy D. ;

Fried, Linda P. .

ARCHIVES OF INTERNAL MEDICINE, 2007, 167 (07) :635-641

[8] Insulin Resistance Is Associated With Decreased Quadriceps Muscle Strength in Nondiabetic Adults Aged ≥70 Years [J].

Barzilay, Joshua I. ;

Cotsonis, George A. ;

Walston, Jeremy ;

Schwartz, Ann V. ;

Satterfield, Suzanne ;

Miljkovic, Iva ;

Harris, Tamara B. .

DIABETES CARE, 2009, 32 (04) :736-738

[9] Is Hyperglycemia Associated with Frailty Status in Older Women? [J].

Blaum, Caroline S. ;

Xue, Qian Li ;

Tian, Jing ;

Semba, Richard D. ;

Fried, Linda P. ;

Walston, Jeremy .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2009, 57 (05) :840-847

[10] Relationship between instrumental activities of daily living and blood glucose control in elderly subjects with type 2 diabetes [J].

Bossoni, S. ;

Mazziotti, G. ;

Gazzaruso, C. ;

Martinelli, D. ;

Orini, S. ;

Solerte, S. B. ;

Romanelli, G. ;

Giustina, A. .

AGE AND AGEING, 2008, 37 (02) :222-225

← 1 2 3 4 5 6 7 8 9 10 →