The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila

被引：305

作者：

Deddouche, Safia ^{[1
]}

Matt, Nicolas ^{[1
]}

Budd, Aidan

Mueller, Stefanie ^{[1
]}

Kemp, Cordula ^{[1
]}

Galiana-Arnoux, Delphine ^{[1
]}

Dostert, Catherine ^{[1
]}

Antoniewski, Christophe ^{[2
]}

Hoffmann, Jules A. ^{[1
]}

Imler, Jean-Luc ^{[1
]}

机构：

[1] Inst Biol Mol & Cellulaire, CNRS, Unite Propre Rech 9022, F-67084 Strasbourg, France

[2] Inst Pasteur, URA2578, CNRS, Dept Dev Biol, F-75724 Paris, France

来源：

NATURE IMMUNOLOGY | 2008年 / 9卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/ni.1664

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Drosophila, like other invertebrates and plants, relies mainly on RNA interference for its defense against viruses. In flies, viral infection also triggers the expression of many genes. One of the genes induced, Vago, encodes a 18-kilodalton cysteine-rich polypeptide. Here we provide genetic evidence that the Vago gene product controlled viral load in the fat body after infection with drosophila C virus. Induction of Vago was dependent on the helicase Dicer-2. Dicer-2 belongs to the same DExD/H-box helicase family as do the RIG-I-like receptors, which sense viral infection and mediate interferon induction in mammals. We propose that this family represents an evolutionary conserved set of sensors that detect viral nucleic acids and direct antiviral responses.

引用

页码：1425 / 1432

页数：8

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